Tenascin-C accelerates adverse ventricular remodelling after myocardial infarction by modulating macrophage polarization

T Kimura, K Tajiri, A Sato, S Sakai, Z Wang… - Cardiovascular …, 2019 - academic.oup.com
Abstract Aims Tenascin-C (TN-C) is an extracellular matrix protein undetected in the normal
adult heart, but expressed in several heart diseases associated with inflammation. We …

Tenascin-C may aggravate left ventricular remodeling and function after myocardial infarction in mice

T Nishioka, K Onishi, N Shimojo… - American Journal …, 2010 - journals.physiology.org
Tenascin-C (TN-C) is an extracellular matrix glycoprotein with high bioactivity. It is
expressed at low levels in normal adult heart, but upregulated under pathological …

Tenascin-c in heart diseases—The role of inflammation

K Imanaka-Yoshida - International Journal of Molecular Sciences, 2021 - mdpi.com
Tenascin-C (TNC) is a large extracellular matrix (ECM) glycoprotein and an original member
of the matricellular protein family. TNC is transiently expressed in the heart during embryonic …

Tenascin-C in tissue repair after myocardial infarction in humans

K Matsui, S Torii, S Hara, K Maruyama, T Arai… - International Journal of …, 2023 - mdpi.com
Adverse ventricular remodeling after myocardial infarction (MI) is progressive ventricular
dilatation associated with heart failure for weeks or months and is currently regarded as the …

Tenascin-C may accelerate cardiac fibrosis by activating macrophages via the integrin αVβ3/nuclear factor–κB/interleukin-6 axis

N Shimojo, R Hashizume, K Kanayama, M Hara… - …, 2015 - Am Heart Assoc
Tenascin-C (TN-C) is an extracellular matrix protein not detected in normal adult heart, but
expressed in several heart diseases closely associated with inflammation. Accumulating …

Tenascin‐C aggravates ventricular dilatation and angiotensin‐converting enzyme activity after myocardial infarction in mice

D Santer, F Nagel, IF Gonçalves, C Kaun… - ESC Heart …, 2020 - Wiley Online Library
Abstract Aims Tenascin‐C (TN‐C) is suggested to be detrimental in cardiac remodelling
after myocardial infarction (MI). The aim of this study is to reveal the effects of TN‐C on …

Tenascin-C in cardiac disease: a sophisticated controller of inflammation, repair, and fibrosis

K Imanaka-Yoshida, I Tawara… - American Journal of …, 2020 - journals.physiology.org
Tenascin-C (TNC) is a large extracellular matrix glycoprotein classified as a matricellular
protein that is generally upregulated at high levels during physiological and pathological …

Interaction between cell and extracellular matrix in heart disease: multiple roles of tenascin-C in tissue remodeling

K Imanaka-Yoshida, M Hiroe… - Histology and …, 2004 - digitum.um.es
The heart remodels myocardial tissue in physiological and pathological response. The
cellextracellular matrix (ECM) interaction provides not only structural and mechanical …

Tenascin-C modulates adhesion of cardiomyocytes to extracellular matrix during tissue remodeling after myocardial infarction

K Imanaka-Yoshida, M Hiroe, T Nishikawa… - Laboratory …, 2001 - nature.com
Abstract Tenascin-C (TNC), an extracellular matrix glycoprotein, plays important roles in
tissue remodeling. TNC is not normally expressed in adults but reappears under pathologic …

Local production of tenascin-C acts as a trigger for monocyte/macrophage recruitment that provokes cardiac dysfunction

D Abbadi, F Laroumanie, M Bizou… - Cardiovascular …, 2018 - academic.oup.com
Abstract Aims Tenascin-C (TNC) is an endogenous danger signal molecule strongly
associated with inflammatory diseases and with poor outcome in patients with …