Background Reports show that stressful events before injury exacerbates post-injury pain.
The mechanism underlying stress-induced heightened thermal pain is unclear. Here, we …

Background The present study aimed to develop a rat model for mechanical allodynia after
traumatic brain injury (TBI) and to investigate the expression of brain-derived neurotrophic …

Chronic pain after traumatic brain injury (TBI) is very common, but the mechanisms linking
TBI to pain experienced in the periphery have not been described. In this set of studies we …

Painful experiences are multilayered, composed of sensory, affective, cognitive and
behavioral facets. Whereas it is well accepted that the development of chronic pain is due to …

We recently demonstrated that exposure to early life stress exacerbates nerve injury-
induced thermal and mechanical hypersensitivity in adult male and female mice …

Stress is a non-specific, systemic, physiological response of the body to strong internal and
external environmental stimuli. Accumulating evidence has suggested that stress …

Traumatic brain injury (TBI) can cause acute and chronic pain along with motor, cognitive,
and emotional problems. Although the mechanisms are poorly understood, previous studies …

Chronic pain with mood disorder, resulting from a peripheral nerve injury, is a serious
clinical problem affecting the quality of life. A lack of brain-derived neurotrophic factor …

Brain-derived neurotrophic factor (BDNF) signals through tropomyosin receptor kinase B
(TrkB), to exert various types of plasticity. The exact involvement of BDNF and TrkB in …

Background Although the brain-derived neurotrophic factor (BDNF) has been intensively
investigated in animal models of chronic pain, its role in human pain processing is less …