[HTML][HTML] HTLV-1 modulates the frequency and phenotype of FoxP3+CD4+T cells in virus-infected individuals

Y Satou, A Utsunomiya, J Tanabe, M Nakagawa… - Retrovirology, 2012 - Springer
Abstract Background HTLV-1 utilizes CD4 T cells as the main host cell and maintains the
proviral load via clonal proliferation of infected CD4+ T cells. Infection of CD4+ T cells by …

High frequency of CD4+FoxP3+ cells in HTLV-1 infection: inverse correlation with HTLV-1–specific CTL response

F Toulza, A Heaps, Y Tanaka, GP Taylor… - Blood, The Journal …, 2008 - ashpublications.org
Evidence from population genetics, gene expression microarrays, and assays of ex vivo T-
cell function indicates that the cytotoxic T lymphocyte (CTL) response to human T …

Adult T cell leukemia/lymphoma: FoxP3+ cells and the cell-mediated immune response to HTLV-1

CRM Bangham, F Toulza - Advances in cancer research, 2011 - Elsevier
Human T-lymphotropic virus type 1 (HTLV-1) causes adult T-cell leukaemia/lymphoma
(ATLL) in∼ 5% of HTLV-1-infected people. ATLL cells frequently express several molecules …

[HTML][HTML] Human T lymphotropic virus type 1 (HTLV-1) proviral load induces activation of T-lymphocytes in asymptomatic carriers

R Coutinho, MFR Grassi, AB Korngold… - BMC Infectious …, 2014 - Springer
Background High HTLV-1 proviral load (PVL) is mainly found in infected individuals with
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). However one third …

[HTML][HTML] HTLV-1 bZIP Factor Induces T-Cell Lymphoma and Systemic Inflammation In Vivo

Y Satou, J Yasunaga, T Zhao, M Yoshida… - PLoS …, 2011 - journals.plos.org
Human T-cell leukemia virus type 1 (HTLV-1) is the causal agent of a neoplastic disease of
CD4+ T cells, adult T-cell leukemia (ATL), and inflammatory diseases including HTLV-1 …

CD8+ T cells are an in vivo reservoir for human T-cell lymphotropic virus type I

M Nagai, MB Brennan, JA Sakai… - Blood, The Journal …, 2001 - ashpublications.org
It is thought that human T-cell lymphotropic virus type I (HTLV-I) preferentially infects CD4+ T
cells in vivo. However, observations of high HTLV-I proviral load in patients with HTLV-I …

[HTML][HTML] Dendritic cell maturation, but not type I interferon exposure, restricts infection by HTLV-1, and viral transmission to T-cells

G Rizkallah, S Alais, N Futsch, Y Tanaka… - PLOS …, 2017 - journals.plos.org
Human T lymphotropic Virus type 1 (HTLV-1) is the etiological agent of Adult T cell
Leukemia/Lymphoma (ATLL) and HTLV-1-Associated Myelopathy/Tropical Spastic …

[HTML][HTML] HTLV-1 bZIP factor induces inflammation through labile Foxp3 expression

N Yamamoto-Taguchi, Y Satou, P Miyazato… - PLoS …, 2013 - journals.plos.org
Human T-cell leukemia virus type 1 (HTLV-1) causes both a neoplastic disease and
inflammatory diseases, including HTLV-1-associated myelopathy/tropical spastic …

High frequencies of Th1-type CD4+ T cells specific to HTLV-1 Env and Tax proteins in patients with HTLV-1–associated myelopathy/tropical spastic paraparesis

PKC Goon, E Hanon, T Igakura… - Blood, The Journal …, 2002 - ashpublications.org
CD4+ T cells are critical for inducing and maintaining efficient humoral and cellular immune
responses to pathogens. The CD4+ T-cell response in human T-lymphotropic virus 1 (HTLV …

[HTML][HTML] HTLV-1 drives vigorous clonal expansion of infected CD8+ T cells in natural infection

A Melamed, DJ Laydon, H Al Khatib, AG Rowan… - Retrovirology, 2015 - Springer
Abstract Background Human T-lymphotropic Virus Type I (HTLV-1) is a retrovirus that
persistently infects 5–10 million individuals worldwide and causes disabling or fatal …