Background: ABC proteins are one key type of transport superfamilies which undertake
majority of drug transport, which affect the osteosarcoma response to chemotherapeutics …

We conducted a comprehensive study to investigate the role of genes involved in transport
pathways in response to chemotherapy and clinical outcome of osteosarcoma cases …

Genetic polymorphisms in drug metabolism and transport genes can influence the
pharmacokinetics and pharmacodynamics of chemotherapy drugs. We investigated the role …

Background ABCG2, also known as BCRP, is a half ATP-binding cassette (ABC) transporter
that localizes to plasma membranes. Recently, a number of studies have investigated the …

Numerous papers have reported ABCB1 polymorphisms are associated with the response
to chemotherapy of cancers. The inconclusive results call for a comprehensive analysis, for …

Background Standard treatment for osteosarcoma patients consists of a combination of
cisplatin, adriamycin, and methotrexate before surgical resection of the primary tumour …

Objective: To investigate the role of three genetic polymorphisms of ABC proteins in
response to chemotherapy and overall survival of osteosarcoma patients. Methods: A …

Objective: Genetic polymorphisms can influence the chemotherapeutic response; however,
previous studies have produced conflicting results, and have failed to identify the most …

Objectives Previous studies showed overexpression of ABCG2 in a variety of tumor tissues,
which could potentially indicate the probability of chemotherapy resistance. This study …

We conducted a comprehensive study to investigate the role of genes involved in metabolic
and transport pathways in response to chemotherapy and clinical outcome of osteosarcoma …