Background: Using small intestinal submucosa (SIS) has increasingly become the standard
method for the treatment of anal fistula. The porcine SIS manufactured by Biosis Healing is a …

Introduction In a recent Cochrane review, the authors concluded that there is an urgent need
for well-powered, well-conducted randomized controlled trials comparing various modes of …

Background Porcine small intestinal submucosa (SIS) is a bioprosthetic collagen material
used in the management of various surgical conditions, especially hernia repairs. We …

BACKGROUND: Bioprosthetic plugs represent a promising technique for the treatment of
anal fistula simple because they allow simple and repeatable application, preservation of …

Background: Anal fistula is an abnormal tract between the anal canal and the perianal skin.
Anal fistula plug (AFP) as a sphincter-preventing method has drawn more interest because …

Purpose Management of anal fistula represents a balance between curing the condition and
maintaining anal continence. Recent reports of the results of the porcine anal fistula plug …

Aim Recent advances in the treatment of fistula‐in‐ano have focused on surgical techniques
that preserve sphincter integrity. Plugs that obliterate the lumen of the fistula track have been …

PURPOSE: The goal in the treatment of anal fistulas is to eliminate the fistula without a
change in continence. No single technique exists that is appropriate for the treatment of all …

Because of the morbidity associated with the performance of anal fistulotomy, especially that
of impairment for bowel control, less invasive options have been advocated in recent years …

Introduction Current treatments for complex anal fistulas are associated with substantial
variability in healing, recurrence, and incontinence rates. This study compared the …