Objective Therapeutic failure of antibiotic therapy has been ascribed to pharmacokinetic
alterations in compromised patient populations. The present study, therefore, aimed at …

Study Objective. To compare the effectiveness of extended‐infusion piperacillin‐tazobactam
with that of similar‐spectrum, nonextended‐infusion β‐lactam antibiotics in the treatment of …

Ten volunteers received piperacillin (4 g), piperacillin (4 g) plus tazobactam (0.5 g)(Tazocin),
and ticarcillin (3 g) plus clavulanic acid (0.2 g)(Timentin) intravenously over 30 min in a …

(1) Background: Piperacillin-tazobactam represents the first-line option for treating infections
caused by full-or multi-susceptible Enterobacterales and/or Pseudomonas aeruginosa in …

Several factors influence the speed of development of antibacterial resistance, among which
is the amount of antibiotic consumption. During the 3-year period 1998-2000, the …

BACKGROUND Recent evidence suggests that current antimicrobial dosing may be
inadequate for some critically ill patients. A major contributor in patients with unimpaired …

This prospective pharmacokinetic study aimed to compare the clearance of piperacillin-
tazobactam administered as a 24-h continuous infusion between continuous venovenous …

Background Pharmacokinetic (PK) and pharmacodynamic (PD) data on perioperative
antibiotic prophylaxis or antibiotic therapy are rare in patients suffering from morbid obesity …

Objective: To discuss the antimicrobial activity, pharmacokinetics, clinical efficacy, and
adverse effect profile of piperacillin/tazobactam, a new beta-lactam/beta-lactamase inhibitor …

Polymicrobial infections are characterized by the presence of micro-organisms from more
than one group of bacteria. Empirical treatment of polymicrobial infections requires an agent …