Viruses cause type 1 diabetes in animals

JIWON YOON, HEES JUN - Annals of the New York Academy …, 2006 - Wiley Online Library
More than 10 viruses have been reported to be associated with the development of type 1
diabetes‐like symptoms in animals, with the best evidence coming from studies on the D …

The role of viruses in type I diabetes: two distinct cellular and molecular pathogenic mechanisms of virus-induced diabetes in animals

HS Jun, JW Yoon - Diabetologia, 2001 - Springer
Type I (insulin-dependent) diabetes mellitus results from the progressive loss of pancreatic
beta cells. Environmental factors are believed to play an important part in the development …

Viruses in type 1 diabetes: brief review

Y Ji-Won, J Hee-Sook - ILAR journal, 2004 - academic.oup.com
Type 1 diabetes results from the progressive destruction of insulin-producing pancreatic
beta cells. Although the etiology of type 1 diabetes is believed to have a major genetic …

Virus-induced diabetes mellitus: IV. Genetic and environmental factors influencing the development of diabetes after infection with the M variant of …

ME Ross, T Onodera, KS Brown, AL Notkins - Diabetes, 1976 - Am Diabetes Assoc
The M variant of encephalomyocarditis virus (EMC) infects pancreatic beta cells and causes
the development of a diabetic syndrome in susceptible strains of mice. By examining four F1 …

Virus-induced diabetes mellitus

JW Yoon, PR McClintock, T Onodera, AL Notkins - J. Exp. Med, 1980 - ncbi.nlm.nih.gov
Beta cells were isolated from strains of mice that were susceptible and resistant to
encephalomyocarditis (EMC) viral-induced diabetes mellitus. Beta cells from susceptible …

Molecular identification of diabetogenic viral gene

YS Bae, HM Eun, JW Yoon - Diabetes, 1989 - Am Diabetes Assoc
The best evidence that viruses have a causative role in the pathogenesis of insulin-
dependent diabetes mellitus comes from experiments in mice infected with …

Virus-induced Diabetes Mellitus: No Evidence for Immune Mechanisms in the Destruction of β-Cells by the D-Variant of Encephalomyocarditis Virus

JW Yoon, PR McClintock, CJ Bachurski… - Diabetes, 1985 - Am Diabetes Assoc
A possible contribution of the immune system to the pathogenesis of virus-induced diabetes
mellitus was investigated using the D-variant of encephalomyocarditis (EMC-D) virus …

Encephalomyocarditis virus-induced diabetes mellitus in mice: model of viral pathogenesis

GW Jordan, SH Cohen - Reviews of infectious diseases, 1987 - academic.oup.com
Encephalomyocarditis (EMC) virus induction of diabetes mellitus in mice has proven to bean
excellent experimental model for the pathogenesis of viral disease. In SJL and DBA/2 mice …

A genetically determined host factor controlling susceptibility to encephalomyocarditis virus-induced diabetes in mice

Y Kang, JW Yoon - Journal of general virology, 1993 - microbiologyresearch.org
Levels of insulin mRNA in pancreata from SJL/J male mice susceptible to
encephalomyocarditis (EMC)-D virus-induced diabetes started to decrease rapidly 24 h after …

Infections that induce autoimmune diabetes in BBDR rats modulate CD4+ CD25+ T cell populations

D Zipris, JL Hillebrands, RM Welsh… - The Journal of …, 2003 - journals.aai.org
Viruses are believed to contribute to the pathogenesis of autoimmune type 1A diabetes in
humans. This pathogenic process can be modeled in the BBDR rat, which develops …