Kilham rat virus (KRV) infection of BB/Wor diabetes-resistant (DR) RT1u rats induces
autoimmune diabetes without direct cytolytic infection of pancreatic β-cells and is a new …

The “M” variant of the encephalomyocarditis (EMC) virus causes a diabetes-like disease in
some, but not all, strains of mice. The genetic basis for either resistance or susceptibility to …

A single administration of complete Freund's adjuvant (CFA), type 1 carrageenan (Car), or
silica 7, 2, and 2 days, respectively, before infection with a low dose (1× 102 plaque-forming …

Insulin‐dependent diabetes mellitus (IDDM) is a multifactorial disease. Besides a genetic
predisposition environmental factors have been implicated in the pathogenesis of β cell …

Monolayers of pancreatic β-cells from strains of mice susceptible (SJL/J) and resistant
(C57BL/6J) to the development of virus-induced diabetes mellitus were inoculated with the …

The D variant of encephalomyocarditis virus (101-105 PFU/head) was intraperitoneally
inoculated into 4 species of small rodents, rats, mice, Syrian hamsters, and Mongolian …

The effect of a known diabetogenic M‐strain encephalomyocarditis (EMC)‐virus in athymic
nude mice (lacking the thymus‐dependent lymphocyte system), and in heterozygous …

The best experimental evidence indicating that viruses have an etiological role in the
pathogenesis of diabetes comes from studies of mice infected with EMC virus. For this study …

In man, the early metabolic abnormalities associated with diabetes mellitus are followed by
various long-term complications1. The cause of these complications is not clear, but they …

Insulin-dependent diabetes mellitus results from destruction of pancreatic beta cells. Viruses
and autoimmunity have been implicated as possible causes of beta cell destruction in …