Insulin-dependent diabetes mellitus (IDDM) results from the destruction of pancreatic beta
cells. Viruses have been suggested as one of the possible causes. The evidence for viruses …

OBJECTIVE The contribution of antecedent viral infection to the development of type 1
diabetes in humans is controversial. Using a newer rat model of the disease, we sought to 1) …

The M variant of encephalomyocarditis virus produces a diabetes mellitus-like disease in
DBA/2 mice but not in animals of the C3H strain. Fewer than one-third of infected F1 (DBA/2 …

Type 1 diabetes (T1D) is an autoimmune disease that is caused by the destruction of insulin-
producing β cells. Viral infections induce immune responses that can damage β cells and …

Insulin-dependent diabetes mellitus (IDDM), also known as type I diabetes, results from the
destruction of pancreatic beta cells. During the past few decades, genetic factors …

Plaque purification of the M variant of encephalomyocarditis (EMC) virus resulted in the
isolation of two stable variants: one diabetogenic and designated D and the other …

The molecular mechanism by which some, but not all, variants of encephalomyocarditis
(EMC) virus selectively infect pancreatic beta-cells in mice and induce IDDM has been an …

EMC virus-induced diabetes in mice may be a model of human type I diabetes. It is
postulated that auto-immune reaction plays a role in beta cell destruction after viral …

To the Editor:“Fulminant” Type 1 diabetes, characterised by diabetic ketoacidosis, low
HbA1c level at onset, insulin deficiency and elevated serum pancreatic enzymes, has been …

Infection of DBA/2N male mice with encephalomyocarditis virus resulted in a diabeteslike
syndrome characterized by hyperglycemia, glycosuria, hypoinsulinemia, polydipsia, and …