Extracellular matrix components as diagnostic tools in inflammatory bowel disease

L Golusda, AA Kühl, B Siegmund, D Paclik - Biology, 2021 - mdpi.com
Simple Summary For decades, the extracellular matrix (ECM) has been defined as a
structure component playing a rather neglected role in the human body. In recent years …

The intestinal tissue homeostasis–the role of extracellular matrix remodeling in inflammatory bowel disease

JH Mortensen, M Lindholm, LL Langholm… - Expert Review of …, 2019 - Taylor & Francis
Introduction: Extracellular matrix (ECM) remodeling of the intestinal tissue is important in
inflammatory bowel disease (IBD) due to the extensive mucosal remodeling. There are still …

Serum Extracellular Matrix Molecules and Their Fragments as Biomarkers of Inflammation and Fibrosis in Inflammatory Bowel Diseases–A Systematic Review

A Poulsen, PD Ovesen, C Lu… - Journal of Crohn's …, 2024 - academic.oup.com
Abstract BACKGROUND AND AIM Contemporary techniques to assess disease activity or
bowel damage in patients with inflammatory bowel disease (IBD), such as endoscopy and …

The role of extracellular matrix components in inflammatory bowel diseases

A Derkacz, P Olczyk, K Olczyk… - Journal of Clinical …, 2021 - mdpi.com
The remodeling of extracellular matrix (ECM) within the intestine tissues, which
simultaneously involves an increased degradation of ECM components and excessive …

The extracellular matrix in IBD: a dynamic mediator of inflammation

AC Petrey, CA de la Motte - Current opinion in gastroenterology, 2017 - journals.lww.com
New studies have offered exciting clues about the function of the ECM during IBD
pathogenesis. The balance of ECM synthesis and turnover is altered in IBD, and the …

Ulcerative colitis, Crohn's disease, and irritable bowel syndrome have different profiles of extracellular matrix turnover, which also reflects disease activity in Crohn's …

JH Mortensen, T Manon-Jensen, MD Jensen… - Plos one, 2017 - journals.plos.org
Background Increased protease activity is a key pathological feature of inflammatory bowel
disease (IBD). However, the differences in extracellular matrix remodelling (ECM) in Crohn's …

Distinct extracellular–matrix remodeling events precede symptoms of inflammation

E Shimshoni, I Adir, R Afik, I Solomonov, A Shenoy… - Matrix biology, 2021 - Elsevier
Identification of early processes leading to complex tissue pathologies, such as inflammatory
bowel diseases,‎ poses a major scientific and clinical challenge that is imperative for …

Inflammatory biomarkers of extracellular matrix remodeling and disease activity in Crohn's disease and ulcerative colitis

V Domislovic, J Høg Mortensen, M Lindholm… - Journal of clinical …, 2022 - mdpi.com
Extracellular matrix (ECM) homeostasis is highly affected in active inflammatory bowel
disease (IBD). The aim of the study was to investigate serological biomarkers of type III, IV …

Extracellular matrix biomarkers in colorectal cancer

MS Kim, SE Ha, M Wu, H Zogg, CF Ronkon… - International journal of …, 2021 - mdpi.com
The cellular microenvironment composition and changes therein play an extremely
important role in cancer development. Changes in the extracellular matrix (ECM), which …

[HTML][HTML] The charming world of the extracellular matrix: a dynamic and protective network of the intestinal wall

S Pompili, G Latella, E Gaudio, R Sferra… - Frontiers in …, 2021 - frontiersin.org
The intestinal extracellular matrix (ECM) represents a complex network of proteins that not
only forms a support structure for resident cells but also interacts closely with them by …