The intestinal wall represents an interactive network regulated by the intestinal epithelium,
extracellular matrix (ECM) and mesenchymal compartment. Under healthy physiological …

In inflammatory bowel disease (IBD), chronic inflammation in the gastrointestinal tract can
lead to tissue damage and remodelling, which can ultimately result in fibrosis. Prolonged …

The aim of our research was to find new biomarkers that could be potentially used in the
diagnosis, differentiation and monitoring of inflammatory bowel diseases (IBD). Since …

The intestinal epithelium is constantly regenerating due to its continuous exposure to the
mechanical and microbial damage from the external environment. Intestinal homeostasis is …

Objective: Inflammatory bowel diseases (IBD) cause chronic intestinal damage and
extracellular matrix (ECM) remodeling. The ECM may play an active role in inflammation by …

The cell microenvironment has a profound influence on the behaviour, growth and survival
of cells. The extracellular matrix (ECM) provides not only mechanical and structural support …

Background and Aims: A hallmark of inflammatory bowel disease [IBD] is chronic
inflammation, which leads to excessive extracellular matrix [ECM] remodelling and release …

The scientific value of re-analyzing existing datasets is often proportional to the complexity of
the data. Proteomics data are inherently complex and can be analyzed at many levels …

Extracellular matrix (ECM) proteins form the structural support for migration of leukocytes
and provide multiple signals to assist in their functions during inflammatory conditions …

Background Chronic intestinal inflammation results in tissue damage partly caused by an
increase in matrix metalloproteinases (MMP) activity causing degradation of extracellular …