Insight on colorectal carcinoma infiltration by studying perilesional extracellular matrix
M Nebuloni, L Albarello, A Andolfo, C Magagnotti… - Scientific reports, 2016 - nature.com
The extracellular matrix (ECM) from perilesional and colorectal carcinoma (CRC), but not
healthy colon, sustains proliferation and invasion of tumor cells. We investigated the …
healthy colon, sustains proliferation and invasion of tumor cells. We investigated the …
Matrix metalloproteinases in inflammatory bowel disease: boon or a bane?
A Ravi, P Garg, SV Sitaraman - Inflammatory bowel diseases, 2007 - academic.oup.com
Matrix metalloproteinases (MMPs) are a family of Zn2+-dependent extracellular matrix
(ECM) degrading endopeptidases that share common functional domains, activation …
(ECM) degrading endopeptidases that share common functional domains, activation …
Inflammation location, but not type, determines the increase in TGF-β1 and IGF-1 expression and collagen deposition in IBD intestine
IC Lawrance, L Maxwell, W Doe - Inflammatory bowel diseases, 2001 - academic.oup.com
Summary Background and Aims Inflammatory bowel disease (IBD) is frequently complicated
by extracellular matrix (ECM) changes that may result in fibrosis. Transforming growth factor …
by extracellular matrix (ECM) changes that may result in fibrosis. Transforming growth factor …
Structural remodeling of the human colonic mesenchyme in inflammatory bowel disease
J Kinchen, HH Chen, K Parikh, A Antanaviciute… - Cell, 2018 - cell.com
Intestinal mesenchymal cells play essential roles in epithelial homeostasis, matrix
remodeling, immunity, and inflammation. But the extent of heterogeneity within the colonic …
remodeling, immunity, and inflammation. But the extent of heterogeneity within the colonic …
Inflammatory Bowel Disease: Immune Function, Tissue Fibrosis and Current Therapies
J Cosín-Roger - International Journal of Molecular Sciences, 2024 - mdpi.com
Inflammatory Bowel Disease (IBD) is a complex and challenging health problem that exerts
a significant impact on the quality of life of millions of individuals worldwide [1]. Although IBD …
a significant impact on the quality of life of millions of individuals worldwide [1]. Although IBD …
Extracellular matrix modulates angiogenesis in physiological and pathological conditions
A Neve, FP Cantatore, N Maruotti… - BioMed research …, 2014 - Wiley Online Library
Angiogenesis is a multistep process driven by a wide range of positive and negative
regulatory factors. Extracellular matrix (ECM) plays a crucial role in the regulation of this …
regulatory factors. Extracellular matrix (ECM) plays a crucial role in the regulation of this …
Basement membrane components
ACY Li, RPH Thompson - Journal of clinical pathology, 2003 - jcp.bmj.com
Idiopathic inflammatory bowel disease (IBD) collectively describes ulcerative colitis (UC)
and Crohn's disease (CD). UC is characterised by inflammation limited to the colonic …
and Crohn's disease (CD). UC is characterised by inflammation limited to the colonic …
Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease
B Von Lampe, B Barthel, SE Coupland, EO Riecken… - Gut, 2000 - gut.bmj.com
BACKGROUND/AIMS Alterations in synthesis and breakdown of extracellular matrix
components are known to play a crucial role in tissue remodelling during inflammation and …
components are known to play a crucial role in tissue remodelling during inflammation and …
[HTML][HTML] Mucosal biomarkers in inflammatory bowel disease: key pathogenic players or disease predictors?
F Scaldaferri, C Correale, A Gasbarrini… - World journal of …, 2010 - ncbi.nlm.nih.gov
Inflammatory bowel diseases (IBDs) are chronic inflammatory disorders of the bowel,
including ulcerative colitis and Crohn's disease. A single etiology has not been identified …
including ulcerative colitis and Crohn's disease. A single etiology has not been identified …