Efficacy and safety of ezetimibe coadministered with pravastatin in patients with primary hypercholesterolemia: a prospective, randomized, double-blind trial

L Melani, R Mills, D Hassman, R Lipetz… - European Heart …, 2003 - academic.oup.com
Aims To evaluate the efficacy and safety of ezetimibe 10mg administered with pravastatin in
patients with primary hypercholesterolemia. Methods and results After dietary stabilization, 2 …

Statins: can the new generation make an impression?

RS Rosenson - Expert opinion on emerging drugs, 2004 - Taylor & Francis
Although large-scale statin trials have demonstrated significant reductions in cardiovascular
risk, there are many patients who have a cardiovascular event despite receiving statin …

Defining the place of ezetimibe/atorvastatin in the management of hyperlipidemia

AM Ferreira, P Marques da Silva - American Journal of Cardiovascular …, 2017 - Springer
Statin–ezetimibe combinations are a potentially advantageous therapeutic option for high-
risk patients who need additional lowering of low-density lipoprotein cholesterol (LDL-C) …

The combination of Ezetimibe and Statin: a new treatment for hypercholesterolemia

S Nodari, P Rocca, A Saporetti, L Bettari… - Heart …, 2007 - journals.sagepub.com
The combination of Simvastatin and Ezetimibe allows dual inhibition of both cholesterol
production and absorption. This treatment approach allows achieving same low serum …

Rosuvastatin in the management of hyperlipidemia

JWM Cheng - Clinical therapeutics, 2004 - Elsevier
BACKGROUND:: Rosuvastatin is a new statin indicated to reduce elevated levels of total
cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglycerides and to increase …

Pharmacokinetic interactions and tolerability of rosuvastatin and ezetimibe: an open-label, randomized, multiple-dose, crossover study in healthy male volunteers

H Kim, HY Choi, YH Kim, KS Bae, J Jung… - Drug design …, 2018 - Taylor & Francis
Purpose Rosuvastatin is a synthetic 3-hydroxy-3-methylglutaryl coenzyme A reductase
inhibitor that effectively reduces low-density lipoprotein cholesterol levels. However, statin …

Pharmacokinetic and pharmacodynamic interaction between ezetimibe and rosuvastatin in healthy male subjects

CH Kim, H An, SH Kim, D Shin - Drug design, development and …, 2017 - Taylor & Francis
Background and objective Rosuvastatin and ezetimibe are commonly applied in lipid-
lowering pharmacotherapy. However, the pharmacokinetic (PK) interaction was not clear by …

Drug insight: the role of statins in combination with ezetimibe to lower LDL cholesterol

AM Gotto Jr, JA Farmer - Nature Clinical Practice Cardiovascular …, 2006 - nature.com
The cardiovascular benefits of therapy with the 3-hydroxy-3-methylglutaryl coenzyme A
reductase inhibitors (statins) are well documented. Undertreatment of dyslipidemia remains …

Fixed‐dose combination ezetimibe+ atorvastatin lowers LDL‐C equivalent to co‐administered components in randomized trials: use of a dose–response model

HE Bays, E Chen, JE Tomassini… - Fundamental & …, 2015 - Wiley Online Library
Co‐administration of ezetimibe with atorvastatin is a generally well‐tolerated treatment
option that reduces LDL‐C levels and improves other lipids with greater efficacy than …

The role of ezetimibe in LDL cholesterol goal attainment in very high risk patients: the rosuvastatin monotherapy looks to be insufficient

L Mark, G Paragh, I Reiber - Current medical research and opinion, 2011 - Taylor & Francis
Full article: The role of ezetimibe in LDL cholesterol goal attainment in very high risk patients:
the rosuvastatin monotherapy looks to be insufficient Skip to Main Content Taylor and Francis …