Background Barth syndrome (BTHS) is a rare genetic disease that is characterized by
cardiomyopathy, skeletal myopathy, neutropenia, and growth abnormalities and often leads …

Mutation of the mitochondrial protein tafazzin causes dilated cardiomyopathy in Barth
syndrome. We employed an adenovirus as a vector to transfer tafazzin small hairpin RNA …

Background: Mutations in tafazzin (TAZ), a gene required for biogenesis of cardiolipin, the
signature phospholipid of the inner mitochondrial membrane, causes Barth syndrome …

Barth Syndrome (BTHS) is an X-linked recessive disorder characterized by cardiomyopathy
and muscle weakness. The underlying cause of BTHS is a mutation in the tafazzin (TAZ) …

Several mitochondrial diseases are caused by pathogenic variants that impair membrane
phospholipid remodeling, with no FDA‐approved therapies. Elamipretide targets the inner …

Mutation of the mitochondrial protein tafazzin causes dilated cardiomyopathy in Barth
syndrome. Previous studies have shown that tafazzin knockdown promotes hypertrophy of …

Rationale: Barth syndrome is an X-linked cardiac and skeletal myopathy caused by mutation
of the gene Tafazzin (TAZ). Currently, there is no targeted treatment for Barth syndrome …

Barth syndrome (BTHS) is a genetic, X-linked, rare but often fatal, pediatric skeletal-and
cardiomyopathy occurring due to mutations in the tafazzin gene (TAZ). TAZ encodes a …

Barth syndrome (BTHS) is an X-linked genetic disorder caused by mutations in the
TAFAZZIN/Taz gene which encodes a transacylase required for cardiolipin remodeling …

Barth syndrome is a multisystem disorder caused by an abnormal metabolism of the
mitochondrial lipid cardiolipin. In this review, we discuss physical properties, biosynthesis …