Background Old age, the most important risk factor for Alzheimer's disease (AD), is
associated with thermoregulatory deficits. Brown adipose tissue (BAT) is the main …

Currently, there are no available approaches to cure or slow down the progression of
Alzheimer's disease (AD), which is characterized by the accumulation of extracellular …

Objective Old age is associated with a rise in the incidence of Alzheimer's disease (AD) but
also with thermoregulatory deficits. Indicative of a link between the two, hypothermia induces …

Alzheimer's disease (AD) is a complex age-related neurodegenerative disease, associated
with central and peripheral metabolic anomalies, such as impaired glucose utilization and …

Accumulation of the neurotoxic β-amyloid protein (Aβ) in the brain is a key step in the
pathogenesis of Alzheimer's disease (AD). Although transgenic mouse models of AD have …

The sharp rise in the incidence of Alzheimer's disease (AD) at an old age coincides with a
reduction in energy metabolism and core body temperature. We found that the triple …

Degeneration of noradrenergic neurons occurs at an early stage of Alzheimer's Disease
(AD). The noradrenergic system regulates arousal and learning and memory, and has been …

Impaired hippocampal neurogenesis is one of the early pathological features of Alzheimer's
disease. Enhancing adult hippocampal neurogenesis has been pursued as a potential …

Alzheimer's disease (AD), the most common cause of age-related dementia, is a progressive
neurodegenerative disorder with an enormous unmet medical need. In recent years, several …

Alzheimer's disease (AD) is a devastating form of dementia that imposes a severe burden on
health systems and society. Although several aspects of AD pathogenesis have been …