Immune regulation in the tumor microenvironment and its relevance in cancer therapy
W Zou - Cellular & Molecular Immunology, 2022 - nature.com
Cancer immunotherapy, including immune checkpoint blockade and CAR-T cell therapy,
has introduced revolutionary approaches to treating patients with cancer. The success and …
has introduced revolutionary approaches to treating patients with cancer. The success and …
Present and future of cancer immunotherapy: A tumor microenvironmental perspective
Y Yu, J Cui - Oncology letters, 2018 - spandidos-publications.com
Modulation of the tumor microenvironment is becoming an increasingly popular research
topic in the field of immunotherapy, and studies regarding immune checkpoint blockades …
topic in the field of immunotherapy, and studies regarding immune checkpoint blockades …
Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy
T Tang, X Huang, G Zhang, Z Hong, X Bai… - Signal transduction and …, 2021 - nature.com
Despite great success in cancer immunotherapy, immune checkpoint-targeting drugs are not
the most popular weapon in the armory of cancer therapy. Accumulating evidence suggests …
the most popular weapon in the armory of cancer therapy. Accumulating evidence suggests …
The influence of microenvironment on tumor immunotherapy
J Zhang, Z Shi, X Xu, Z Yu, J Mi - The FEBS journal, 2019 - Wiley Online Library
Tumor immunotherapy has achieved remarkable efficacy, with immune‐checkpoint
inhibitors as especially promising candidates for cancer therapy. However, some issues …
inhibitors as especially promising candidates for cancer therapy. However, some issues …
Targeting the tumor microenvironment for improving therapeutic effectiveness in cancer immunotherapy: focusing on immune checkpoint inhibitors and combination …
IT Chyuan, CL Chu, PN Hsu - Cancers, 2021 - mdpi.com
Simple Summary Immune checkpoint inhibitors (ICIs) constitute a paradigm shift in cancer
therapy, and it has greatly expanded our knowledge of anticancer immunity and has …
therapy, and it has greatly expanded our knowledge of anticancer immunity and has …
Immunosuppressive tumor microenvironment modulation by chemotherapies and targeted therapies to enhance immunotherapy effectiveness
R Barnestein, L Galland, L Kalfeist, F Ghiringhelli… - …, 2022 - Taylor & Francis
With the rapid clinical development of immune checkpoint inhibitors (ICIs), the standard of
care in cancer management has evolved rapidly. However, immunotherapy is not currently …
care in cancer management has evolved rapidly. However, immunotherapy is not currently …
Immune cells within the tumor microenvironment: Biological functions and roles in cancer immunotherapy
X Lei, Y Lei, JK Li, WX Du, RG Li, J Yang, J Li, F Li… - Cancer letters, 2020 - Elsevier
The immune cells within the tumor microenvironment (TME) play important roles in
tumorigenesis. It has been known that these tumor associated immune cells may possess …
tumorigenesis. It has been known that these tumor associated immune cells may possess …
The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications
Immunotherapy has revolutionized cancer treatment and rejuvenated the field of tumor
immunology. Several types of immunotherapy, including adoptive cell transfer (ACT) and …
immunology. Several types of immunotherapy, including adoptive cell transfer (ACT) and …
Immune suppressive mechanisms in the tumor microenvironment
DH Munn, V Bronte - Current opinion in immunology, 2016 - Elsevier
Highlights•Tumors exaggerate and exploit natural immunosuppressive and tolerogenic
mechanisms.•This milieu favors angiogenesis and tissue remodeling but is suppressive for T …
mechanisms.•This milieu favors angiogenesis and tissue remodeling but is suppressive for T …
Tissue site and the cancer immunity cycle
Checkpoint blockade immunotherapy (CBT) has revolutionized cancer treatment; however,
the cellular and molecular factors that govern responsiveness to immunotherapy remain …
the cellular and molecular factors that govern responsiveness to immunotherapy remain …