The protective effect of decoction of Rehmanniae via PI3K/Akt/mTOR pathway in MPP+-induced Parkinson's disease model cells
D Jiang, Y Peng - Journal of Receptors and Signal Transduction, 2021 - Taylor & Francis
This research aims to explore the function of DOR in 1-methyl-4-phenylpyridinium (MPP+)-
induced Parkinson's disease model cell SH-SY5Y. SH-SY5Y cells were exposed with …
induced Parkinson's disease model cell SH-SY5Y. SH-SY5Y cells were exposed with …
Miltirone Attenuates Reactive Oxygen Species-Dependent Neuronal Apoptosis in MPP+-Induced Cell Model of Parkinson's Disease Through Regulating the PI3K/Akt …
H Feng, F Xi - Neurochemical Research, 2022 - Springer
Miltirone is a phenanthrene-quinone derived from Salvia miltiorrhiza Bunge with anti-
inflammatory and anti-oxidant effects. Our study aimed to explore the protective effect of …
inflammatory and anti-oxidant effects. Our study aimed to explore the protective effect of …
Tyrosol exerts a protective effect against dopaminergic neuronal cell death in in vitro model of Parkinson's disease
Experimental evidence suggests that tyrosol [2-(4-hydroxyphenyl) ethanol] exhibits potent
protective activities against several pathogeneses. In this study, we evaluated the protective …
protective activities against several pathogeneses. In this study, we evaluated the protective …
Echinacoside Protects Against MPP+-Induced Neuronal Apoptosis via ROS/ATF3/CHOP Pathway Regulation
Q Zhao, X Yang, D Cai, L Ye, Y Hou, L Zhang… - Neuroscience …, 2016 - Springer
Echinacoside (ECH) is protective in a mouse model of Parkinson's disease (PD) induced by
1-methyl-4-phenylpyridinium ion (MPP+). To investigate the mechanisms involved, SH …
1-methyl-4-phenylpyridinium ion (MPP+). To investigate the mechanisms involved, SH …
Protection afforded by quercetin against H2O2-induced apoptosis on PC12 cells via activating PI3K/Akt signal pathway
L Chen, L Sun, Z Liu, H Wang, C Xu - Journal of Receptors and …, 2016 - Taylor & Francis
Cell damage and apoptosis induced by oxidative stress have been involved in various
neurodegenerative diseases. This study aims to explore the neuro-protective effects of …
neurodegenerative diseases. This study aims to explore the neuro-protective effects of …
Tetrahydroxystilbene glucoside attenuates MPP+-induced apoptosis in PC12 cells by inhibiting ROS generation and modulating JNK activation
X Li, Y Li, J Chen, J Sun, X Li, X Sun, X Kang - Neuroscience Letters, 2010 - Elsevier
It is known that oxidative stress plays a major role in the progression of Parkinson's disease
(PD). Previous studies have suggested that 2, 3, 5, 4′-tetrahydroxystilbene-2-O-β-d …
(PD). Previous studies have suggested that 2, 3, 5, 4′-tetrahydroxystilbene-2-O-β-d …
[HTML][HTML] Radix Ophiopogonis polysaccharide extracts alleviate MPP+-induced PC-12 cell injury through inhibition of Notch signaling pathway
R Liu, X Li - International Journal of Clinical and Experimental …, 2018 - ncbi.nlm.nih.gov
Background: Parkinson's disease (PD) is a degenerative disease of central nervous system.
1-Methyl-4-phenylpyridine (MPP+) is a non-selective dopaminergic neurotoxin that induces …
1-Methyl-4-phenylpyridine (MPP+) is a non-selective dopaminergic neurotoxin that induces …
Involvement of activation of PI3K/Akt pathway in the protective effects of puerarin against MPP+-induced human neuroblastoma SH-SY5Y cell death
G Zhu, X Wang, S Wu, Q Li - Neurochemistry international, 2012 - Elsevier
In an attempt to clarify the protective effect of puerarin on toxin-insulted dopaminergic
neuronal death, this present study was carried out by using a typical Parkinson's disease …
neuronal death, this present study was carried out by using a typical Parkinson's disease …
Implication of the c-Jun-NH2-terminal kinase pathway in the neuroprotective effect of puerarin against 1-methyl-4-phenylpyridinium (MPP+)-induced apoptosis in PC …
G Wang, L Zhou, Y Zhang, M Dong, X Li, J Liu… - Neuroscience Letters, 2011 - Elsevier
Apoptosis is a widely accepted component of the pathogenesis of Parkinson's disease (PD),
a debilitating neurodegenerative disorder characterized by loss of dopaminergic neurons in …
a debilitating neurodegenerative disorder characterized by loss of dopaminergic neurons in …
Involvement of ubiquitin proteasome system in protective mechanisms of Puerarin to MPP+-elicited apoptosis
It has been well documented that dysfunction of ubiquitin proteasome system (UPS) in the
neuron exacerbated the Parkinson's disease (PD). However, whether or not UPS is involved …
neuron exacerbated the Parkinson's disease (PD). However, whether or not UPS is involved …