Substance P prevents 1-methyl-4-phenylpyridinium-induced cytotoxicity through inhibition of apoptosis via neurokinin-1 receptors in MES23. 5 cells

SY Wang, L Chen, Y Xue… - Molecular Medicine …, 2015 - spandidos-publications.com
Abstract [Sar9, Met (O2) 11] termed Substance P (SP), is an effective and selective agonist
for the neurokinin‑1 (NK‑1) receptors, which are synthetic peptides, similar in structure to SP …

Okadaic acid protects human neuroblastoma SH-SY5Y cells from 1-methyl-4-phenylpyridinium ion-induced apoptosis

KH Ahn, YS Kim, SY Kim, Y Huh, C Park, JW Jeong - Neuroscience letters, 2009 - Elsevier
1-Methyl-4-phenylpyridinium ion (MPP+) has been shown to selectively inhibit mitochondrial
function and induce a parkinsonism-like syndrome. MPP+ stimulates the production of …

Neuroprotective effect of Korea Red Ginseng extract on 1-methyl-4-phenylpyridinium-induced apoptosis in PC12 Cells

S Ryu, S Koo, KT Ha, S Kim - Animal Cells and Systems, 2016 - Taylor & Francis
ABSTRACT Background: Korean Red Ginseng (KRG) is a valuable herb in Asian countries
that is used as a crude substance to inhibit inflammation and to enhance vitality, longevity …

Myricetin attenuated MPP+-induced cytotoxicity by anti-oxidation and inhibition of MKK4 and JNK activation in MES23. 5 cells

K Zhang, ZG Ma, J Wang, AM Xie, JX Xie - Neuropharmacology, 2011 - Elsevier
Increasing evidence suggests that oxidative stress may be implicated in the degeneration of
dopaminergic neurons in Parkinson's disease (PD), and anti-oxidation have been shown to …

Icariside II suppresses ferroptosis to protect against MPP+-Induced Parkinson's disease through Keap1/Nrf2/GPX4 signaling

W Fan, J Zhou - Journal of Physiological Investigation, 2023 - journals.lww.com
Parkinson's disease (PD) is recognized as a degenerative and debilitating
neurodegenerative disorder. The novel protective role of icariside II (ICS II) as a plant …

Naringenin protects against 1-methyl-4-phenylpyridinium-induced neuroinflammation and resulting reactive oxygen species production in SH-SY5Y cell line: An in …

S Mani, S Sekar, SB Chidambaram… - Pharmacognosy …, 2018 - phcog.com
Background: Parkinson's disease is a progressive neurodegenerative disorder which affects
1% of the population worldwide. It is well known that 1-methyl-4-phenylpyridinium (MPP+) …

Citronellol prevents 6-OHDA-induced oxidative stress, mitochondrial dysfunction, and apoptosis in Parkinson disease model of SH-SY5Y cells via modulating ROS …

J Shao, X Liu, M Lian, Y Mao - Neurotoxicity Research, 2022 - Springer
Parkinson disease is a neurodegenerative disorder distinguished by dopaminergic shortage
in the striatum and the accumulation of α-synuclein neuronal aggregates in the brains of …

Genkwanin suppresses MPP+-induced cytotoxicity by inhibiting TLR4/MyD88/NLRP3 inflammasome pathway in a cellular model of Parkinson's disease

Q Li, P Zhang, Y Cai - Neurotoxicology, 2021 - Elsevier
Parkinson's disease (PD) is a complicated multifactorial neurodegenerative disorder.
Oxidative stress, neuroinflammatory response, and activation of apoptosis have been …

Neuroprotective Effects of Carpinus tschonoskii MAX on 6-Hydroxydopamine-Induced Death of PC12 Cells

KIM Min-Kyoung, KIM Sang-Cheol, K Jung-Il… - Biomolecules & …, 2010 - biomolther.org
The present study investigated the neuroprotective effect of Carpinus tschonoskii MAX and
its intracellular protective mechanism on 6-hydroxydopamine (6-OHDA)-induced oxidative …

Protection by puerarin against MPP+-induced neurotoxicity in PC12 cells mediated by inhibiting mitochondrial dysfunction and caspase-3-like activation

J Bo, BY Ming, LZ Gang, C Lei, AL Jia - Neuroscience research, 2005 - Elsevier
Puerarin, a main isoflavone glycoside distributed in Pueraria lobata (Willd.) Ohwi, showed
inhibitory activity on H2O2-induced PC12 cells damage in our previous work. However …