Tanshinone IIA protects dopaminergic neurons against 6-hydroxydopamine-induced neurotoxicity through miR-153/NF-E2-related factor 2/antioxidant response …

XS Zhang, S Ha, XL Wang, YL Shi, SS Duan, ZA Li - Neuroscience, 2015 - Elsevier
Parkinson's disease (PD) is the second most common progressive neurodegenerative
disorder with increased oxidative stress, the underlying vital process contributing to cell …

Salidroside protected against MPP+‐induced Parkinson's disease in PC12 cells by inhibiting inflammation, oxidative stress and cell apoptosis

F Zhou, J Ju, Y Fang, X Fan, S Yan… - Biotechnology and …, 2019 - Wiley Online Library
The present study aimed to investigate the protective effects of salidroside (SAL) on 1‐
methyl‐4‐phenylpyridinium (MPP+)‐induced PC12 cell model for Parkinson's disease …

[HTML][HTML] α-Cyperone Attenuates H2O2-Induced Oxidative Stress and Apoptosis in SH-SY5Y Cells via Activation of Nrf2

B Huang, J Liu, S Fu, Y Zhang, Y Li, D He… - Frontiers in …, 2020 - frontiersin.org
α-Cyperone, extracted from Cyperus rotundus, has been reported to inhibit microglia-
mediated neuroinflammation. Oxidative stress and apoptosis play crucial roles in the course …

Protection against MPP+-induced neurotoxicity in SH-SY5Y cells by tormentic acid via the activation of PI3-K/Akt/GSK3β pathway

Q Zhao, J Ye, N Wei, C Fong, X Dong - Neurochemistry International, 2016 - Elsevier
The cause of Parkinson's disease (PD) could be ascribed to the progressive and selective
loss of dopaminergic neurons in the substantia nigra pars compacta, and thus molecules …

Zingerone activates VMAT2 during MPP+‐induced Cell Death

JS Choi, WY Bae, C Park, JW Jeong - Phytotherapy Research, 2015 - Wiley Online Library
Parkinson's disease (PD) is characterized by a progressive and selective loss of
dopaminergic neurons in the substantia nigra pars compacta (SNpc) and striatum. 1‐Methyl …

[HTML][HTML] Tilianin attenuates MPP+‑induced oxidative stress and apoptosis of dopaminergic neurons in a cellular model of Parkinson's disease

J Li, S Xu - Experimental and Therapeutic Medicine, 2022 - spandidos-publications.com
The flavonoid tilianin is derived from the leaves of Dracocephalum moldavica L. amiales and
has been proven to serve a neuroprotective role in cerebral ischemia. Therefore, the aim of …

Effect of a Traditional Chinese Herbal Medicine Formulation on Cell Survival and Apoptosis of MPP+‐Treated MES 23.5 Dopaminergic Cells

S Ye, HK Koon, W Fan, Y Xu, W Wei, C Xu… - Parkinson's …, 2017 - Wiley Online Library
Progressive degeneration of dopaminergic neurons in the substantia nigra (SN) is
implicated in Parkinson's disease (PD). The efficacy of these currently used drugs is limited …

Mechanisms of MPP+-induced PC12 cell apoptosis via reactive oxygen species

Q Zhu, J Wang, Y Zhang, S Sun - … of Huazhong University of Science and …, 2012 - Springer
Apoptosis of dopaminergic neurons in the nigrostriatal projection plays a crucial role in the
pathogenesis of Parkinson's disease (PD). Although the detailed mechanisms responsible …

Humulus japonicus Prevents Dopaminergic Neuron Death in 6-Hydroxydopamine-Induced Models of Parkinson's Disease

YK Ryu, Y Kang, J Go, HY Park, JR Noh… - Journal of medicinal …, 2017 - liebertpub.com
Humulus japonicus (HJ), popularly known as Japanese hops, is a traditional herbal
medicine widely used for the treatment of pulmonary disease, skin disease, and …

[HTML][HTML] Rosmarinic acid attenuates rotenone-induced neurotoxicity in SH-SY5Y Parkinson's disease cell model through abl inhibition

X Han, B Han, Y Zhao, G Li, T Wang, J He, W Du… - Nutrients, 2022 - mdpi.com
Rosmarinic acid (RA) is a natural polyphenolic compound with antioxidative property. With
the present study, we aimed to evaluate the neuroprotective role of RA on Parkinson's …