Determining the effect of DNA methylation on chromatin structure and function in higher
organisms is challenging due to the extreme complexity of epigenetic regulation. We studied …

Dynamic three-dimensional chromatin conformation is a critical mechanism for gene
regulation during development and disease. Despite this, profiling of three-dimensional …

The relationship between DNA methylation and chromatin structure is still largely unknown.
By analyzing a large set of published sequencing data, we observed a long-range power …

Cytosine DNA methylation is a highly conserved epigenetic mark in eukaryotes. Although
the role of DNA methylation at gene promoters and repetitive elements has been extensively …

DNA replication timing and three-dimensional (3D) genome organization are associated
with distinct epigenome patterns across large domains. However, whether alterations in the …

Methylation of cytosines (5meC) is a widespread heritable DNA modification. During
mammalian development, two global demethylation events are followed by waves of de …

Methylation of cytosines is the key epigenetic modification of DNA in eukaryotes and is
associated with a repressed chromatin state and inhibition of gene expression. The …

DNA methylation plays a vital role in epigenetic regulation in both plants and animals, and
typically occurs at the 5-carbon position of the cytosine pyrimidine ring within the CpG …

DNA methylation has an essential regulatory function in mammalian development, serving
to repress nontranscribed genes stably in differentiated adult somatic cells. Recent data …

DNA methylation and histone modification are two major epigenetic pathways that interplay
to regulate transcriptional activity and other genome functions. Dnmt3L is a regulatory factor …