Aims Reactive oxygen species are reportedly involved in the mechanism underlying heart
failure with preserved ejection fraction (HFpEF); however, the disease pathophysiology …

Background Oxidative stress due to purine degradation is associated with the development
of chronic heart failure (CHF). Xanthine oxidoreductase (XOR) is a rate-limiting enzyme of …

Background and purpose Xanthine oxidoreductase (XOR), which catalyzes purine
catabolism, has two interconvertible forms, xanthine dehydrogenase and xanthine oxidase …

Aims Plasma xanthine oxidoreductase (XOR) activity during the acute phase of acute heart
failure (AHF) requires further elucidation. Methods and results One hundred eighteen AHF …

Background Xanthine oxidoreductase (XOR) is a rate-limiting enzyme for uric acid (UA)
production and plays an important role in generating reactive oxygen species (ROS) …

Background—Oxidative stress may contribute to heart failure (HF) progression. Inhibiting
xanthine oxidase in hyperuricemic HF patients may improve outcomes. Methods and …

BACKGROUND: Reactive oxygen species (ROS) have been linked to hypertrophy,
remodeling and abnormal excitation-contraction coupling. Previous data demonstrated that …

The role of hyperuricaemia as cardiovascular risk factor has exhaustingly been debated for
decades. While the association of elevated uric acid (UA) levels with increased mortality risk …

Background: Elevated xanthine oxidase (X0) activity contributes to production of reactive
oxygen species. Hyperuicemia is common in chronic heart failure (CHF), however, enzyme …

Background: The mechanisms of the increased plasma xanthine oxidoreductase (XOR)
activity in outpatients with cardiovascular disease were unclear. Methods and Results: A …