This review article discusses the challenges of delivering cargoes to the cytoplasm, for
example, proteins, peptides, and nucleic acids, and the mechanisms involved in endosomal …

During the last decade, cell-penetrating peptides have been investigated for their ability to
overcome the plasma membrane barrier of mammalian cells for the intracellular or …

Intracellular delivery of biological agents such as peptides, proteins, and nucleic acids
generally rely on the endocytic pathway as the major uptake mechanism, resulting in their …

The insides of cells can be viewed as a treasure trove of targets for therapeutic intervention
of diseases or as deposits for contrasting agents. Increasingly the molecules that need to be …

Cell penetrating peptides facilitate efficient intracellular uptake of diverse materials ranging
from small contrast agents to larger proteins and nanoparticles. However, a significant …

Cellular machinery is protected from the surrounding by two-layer lipid membrane that is
impermeable for most substances unnecessary for cellular metabolism. Unfortunately, from …

Protein-based nanocarriers are versatile and biocompatible drug delivery systems. They are
of particular interest in nanomedicine as they can recruit multiple functions in a single …

Conspectus The interfacing of nanomaterials and especially nanoparticles within all aspects
of biological research continues to grow at a nearly unabated pace with projected …

To develop novel therapies for clinical treatments, it increasingly depends on sophisticated
delivery systems that facilitate the drugs entry into targeting cells. Profound understanding of …

In 1988, two unrelated papers reported the discovery of peptide vectors with innate cell
translocation properties, setting the ground for a new area of research that over the years …