Cells interact with various nanoscaled topographical and biochemical cues in their cellular
macromolecular environment. Nanotopography recreates or mimic the cellular …

The rapid development of fabrication and processing technologies in the past two decades
has enabled researchers to introduce nanoscale features into materials which, interestingly …

The natural cell environment provides a variety of chemical, topographical and mechanical
stimuli that contribute in regulating cell behavior and function. If considerable effort has been …

Stem cells have been one of the ideal sources for tissue regeneration owing to their
capability of self-renewal and differentiation. In vivo, the extracellular microenvironment …

Stem cells have the capacity to differentiate into various lineages, and the ability to reliably
direct stem cell fate determination would have tremendous potential for basic research and …

In bone tissue engineering, it is desirable to use materials to control the differentiation of
mesenchymal stem cell populations in order to gain direct bone apposition to implant …

Topography was first identified to influence cell behaviour as early as 1911 when RG
Harrison observed the guidance of cells along the fibres of a spider's web (Harrison 1911) …

Stem cells are unspecialized cells that can self renew indefinitely and differentiate into
several somatic cells given the correct environmental cues. In the stem cell niche, stem cell …

Current load-bearing orthopaedic implants are produced in 'bio-inert'materials such as
titanium alloys. When inserted into the reamed bone during hip or knee replacement surgery …

In this paper, we report the initial response of 3T3 fibroblast and MG63 osteoblast cells to
engineered nanotopography gradients of three nanoparticle diameters (16 nm, 38 nm and …