Increased Breadth of Group A Streptococcus Antibody Responses in Children With Acute Rheumatic Fever Compared to Precursor Pharyngitis and Skin Infections

AL Whitcombe, R McGregor, J Bennett… - The Journal of …, 2022 - academic.oup.com
Abstract Background Group A Streptococcus (GAS) causes superficial pharyngitis and skin
infections as well as serious autoimmune sequelae such as acute rheumatic fever (ARF) …

Comparison of group A streptococcal titres in healthy children and those with pharyngitis and skin infections

J Bennett, NJ Moreland, DA Williamson, J Carapetis… - Journal of Infection, 2022 - Elsevier
Objectives Rates of acute rheumatic fever, a sequelae of group A Streptococcal (GAS)
infection, remain unacceptably high in Indigenous Māori and Pacific children in New …

Understanding group A streptococcal pharyngitis and skin infections as causes of rheumatic fever: protocol for a prospective disease incidence study

J Bennett, NJ Moreland, J Oliver, J Crane… - BMC Infectious …, 2019 - Springer
Abstract Background Group A Streptococcal (GAS) infections cause the autoimmune
disease acute rheumatic fever (ARF), which can progress to chronic rheumatic heart disease …

Acute rheumatic fever: clinical aspects and insights into pathogenesis and prevention

JA Guzman-Cottrill, P Jaggi, ST Shulman - Clinical and Applied …, 2004 - Elsevier
Acute rheumatic fever (ARF) is an inflammatory disease of childhood that occurs following
untreated Group A streptococcal pharyngeal infections. Although it is well established that …

Streptococcal serology in acute rheumatic fever patients: findings from 2 high-income, high-burden settings

S Jack, NJ Moreland, J Meagher, M Fittock… - The Pediatric …, 2019 - journals.lww.com
Background: Globally, there is wide variation in streptococcal titer upper limits of normal
(ULN) for antistreptolysin O (ASO) and anti-deoxyribonuclease B (ADB) used as an …

Antibody responses to group A streptococcal infections in acute rheumatic fever

TB Martins, LG Veasy, HR Hill - The Pediatric infectious disease …, 2006 - journals.lww.com
Acute rheumatic fever (ARF) is a nonsuppurative sequela of group A streptococcal
pharyngitis. It is a multifocal inflammatory disease, affecting primarily the joints, heart, central …

The novel group A Streptococcus antigen SpnA combined with bead-based immunoassay technology improves streptococcal serology for the diagnosis of acute …

P Hanson-Manful, AL Whitcombe, PG Young… - Journal of Infection, 2018 - Elsevier
Objectives Streptococcal serology provides evidence of prior Group A Streptococcus (GAS)
exposure, crucial to the diagnosis of acute rheumatic fever (ARF) and post-streptococcal …

Acute rheumatic fever after group A Streptococcus pyoderma and group G Streptococcus pharyngitis

L O'Sullivan, NJ Moreland, RH Webb… - The Pediatric …, 2017 - journals.lww.com
A case of acute rheumatic fever (ARF) in an Indigenous Maori child in New Zealand after
Group A Streptococcus pyoderma and Group G Streptococcus pharyngitis is reported. The …

Risk factors for group A streptococcal pharyngitis and skin infections: a case control study

J Bennett, NJ Moreland, J Zhang, J Crane… - The Lancet Regional …, 2022 - thelancet.com
Summary Background Group A streptococcal (GAS) infections can trigger an immune-
mediated response resulting in acute rheumatic fever (ARF). The role of social and …

Prospective longitudinal analysis of immune responses in pediatric subjects after pharyngeal acquisition of group A streptococci

ND Hysmith, EL Kaplan, PP Cleary… - Journal of the …, 2017 - academic.oup.com
Background. Despite the significant burden of disease associated with infection by group A s
treptococcus (GAS), little is known about the human immune response to GAS antigens after …