Oxidized phospholipids as a unifying theory for lipoprotein (a) and cardiovascular disease

MB Boffa, ML Koschinsky - Nature Reviews Cardiology, 2019 - nature.com
Epidemiological and clinical studies over the past decade have firmly established that
elevated plasma concentrations of lipoprotein (a)(Lp (a)) are an important, independent and …

Report of the National Heart, Lung, and Blood Institute Workshop on Lipoprotein (a) and Cardiovascular Disease: recent advances and future directions

SM Marcovina, ML Koschinsky, JJ Albers… - Clinical …, 2003 - academic.oup.com
It has been estimated that∼ 37% of the US population judged to be at high risk for
developing coronary artery disease (CAD), based on the National Cholesterol Education …

Lipoprotein (a) and ethnicities

A Mehta, V Jain, A Saeed, JJ Saseen, M Gulati… - Atherosclerosis, 2022 - Elsevier
The initial studies focusing on lipoprotein (a)[Lp (a)] and its role in atherosclerotic
cardiovascular disease were conducted exclusively in Whites. Subsequently, multiple large …

High levels of inflammatory biomarkers are associated with increased allele-specific apolipoprotein (a) levels in African-Americans

E Anuurad, J Rubin, A Chiem, RP Tracy… - The Journal of …, 2008 - academic.oup.com
Background: A role of inflammation for cardiovascular disease (CVD) is established.
Lipoprotein (a)[Lp (a)] is an independent CVD risk factor where plasma levels are …

IL-6 blockade by monoclonal antibodies inhibits apolipoprotein (a) expression and lipoprotein (a) synthesis in humans

N Müller, DM Schulte, K Türk, S Freitag-Wolf… - Journal of lipid …, 2015 - ASBMB
Lipoprotein (a)[Lp (a)] is a highly atherogenic lipid particle. Although earlier reports
suggested that Lp (a) levels are mostly determined by genetic factors, several recent studies …

Screening for high lipoprotein (a) the time is now

G Thanassoulis - Circulation, 2019 - Am Heart Assoc
In 1994, the landmark 4S trial (Scandinavian Simvastatin Survival Study) reported that
lowering low-density lipoprotein (LDL) cholesterol with simvastatin reduced cardiovascular …

Lipoprotein (a)

M Koschinsky, SM Marcovina - Clinical lipidology: a companion …, 2009 - books.google.com
Although numerous studies since the 1960s have identified increased plasma
concentrations of lipoprotein (a)[Lp (a)] as a risk factor for coronary heart disease (CHD), the …

Lipoprotein (a) and vascular disease: thrombogenesis and atherogenesis

GYH Lip, AF Jones - QJM: An International Journal of Medicine, 1995 - academic.oup.com
Abstract Lipoprotein (a)[Lp (a)] has been recognized for nearly 30 years, and increasingly,
associated with the processes of atherogenesis and thrombogenesis. Despite this, the …

Interleukin-1 genotypes modulate the long-term effect of lipoprotein (a) on cardiovascular events: The Ioannina Study

KK Naka, A Bechlioullis, A Marini, D Sionis… - Journal of Clinical …, 2018 - Elsevier
Background Lipoprotein (a)[Lp (a)] is a genetic risk factor for cardiovascular disease (CVD),
and proinflammatory interleukin-1 (IL-1) genotypes may influence Lp (a)-mediated CVD …

Role of lipoprotein (a) in atherosclerotic cardiovascular disease: A review of current and emerging therapies

IS Alhomoud, A Talasaz, A Mehta… - … : The Journal of …, 2023 - Wiley Online Library
Abstract Lipoprotein (a), or Lp (a), is structurally like low‐density lipoprotein (LDL) but differs
in that it contains glycoprotein apolipoprotein (a)[apo (a)]. Due to its prothrombotic and …