Sen1 is an essential helicase for factor-dependent transcription termination in
Saccharomyces cerevisiae, whose molecular-motor mechanism has not been well …

Pervasive transcription is widespread and needs to be controlled in order to avoid
interference with gene expression. In Saccharomyces cerevisiae, the highly conserved …

Transcription termination is essential to generate functional RNAs and to prevent disruptive
polymerase collisions resulting from concurrent transcription. The yeast Sen1p helicase is …

In the yeast Saccharomyces cerevisiae, the essential nuclear helicase Sen1 is required for
efficient termination of transcription of short noncoding RNA genes by RNA polymerase II …

Pervasive transcription is a widespread phenomenon leading to the production of a plethora
of non‐coding RNA s (nc RNA s) without apparent function. Pervasive transcription poses a …

Abstract The superfamily 1B (SF 1B) helicase Sen1 is an essential protein that plays a key
role in the termination of non‐coding transcription in yeast. Here, we identified the~ 90 kDa …

Transcriptome studies on eukaryotic cells have revealed an unexpected abundance and
diversity of noncoding RNAs synthesized by RNA polymerase II (Pol II), some of which …

Extrinsic transcription termination typically involves remodeling of RNA polymerase by an
accessory helicase. In yeast this is accomplished by the Sen1 helicase homologous to …

Sen1 of S. cerevisiae is a known component of the NRD complex implicated in transcription
termination of nonpolyadenylated as well as some polyadenylated RNA polymerase II …

Pervasive transcription is a universal phenomenon leading to the production of a plethora of
non-coding RNAs. If left uncontrolled, pervasive transcription can be harmful for genome …