The Pseudomonas aeruginosa Type III secretion system exoenzyme effector ExoU induces mitochondrial damage in a murine bone marrow-derived macrophage …

KS Hardy, AN Tuckey, NA Housley… - Infection and …, 2022 - Am Soc Microbiol
Pseudomonas aeruginosa is a Gram-negative, opportunistic pathogen that causes
nosocomial pneumonia, urinary tract infections, and bacteremia. A hallmark of P. aeruginosa …

ExoU Induces Lung Endothelial Cell Damage and Activates Pro-Inflammatory Caspase-1 during Pseudomonas aeruginosa Infection

KS Hardy, AN Tuckey, P Renema, M Patel… - Toxins, 2022 - mdpi.com
The Gram-negative, opportunistic pathogen Pseudomonas aeruginosa utilizes a type III
secretion system to inject exoenzyme effectors into a target host cell. Of the four best-studied …

Perspectives on the Pseudomonas aeruginosa Type III Secretion System Effector ExoU and Its Subversion of the Host Innate Immune Response to Infection

KS Hardy, MH Tessmer, DW Frank, JP Audia - Toxins, 2021 - mdpi.com
Pseudomonas aeruginosa is an opportunistic, Gram-negative pathogen and an important
cause of hospital acquired infections, especially in immunocompromised patients. Highly …

Different domains of Pseudomonas aeruginosa exoenzyme S activate distinct TLRs

S Epelman, D Stack, C Bell, E Wong… - The Journal of …, 2004 - journals.aai.org
Some bacterial products possess multiple immunomodulatory effects and thereby complex
mechanisms of action. Exogenous administration of an important Pseudomonas aeruginosa …

Pseudomonas aeruginosa ExoT induces mitochondrial apoptosis in target host cells in a manner that depends on its GTPase-activating protein (GAP) domain activity

SJ Wood, JW Goldufsky, D Bello, S Masood… - Journal of Biological …, 2015 - ASBMB
Pseudomonas aeruginosa is the most common cause of hospital-acquired pneumonia and
a killer of immunocompromised patients. We and others have demonstrated that the type III …

[HTML][HTML] ExoS Effector in Pseudomonas aeruginosa Hyperactive Type III Secretion System Mutant Promotes Enhanced Plasma Membrane Rupture in Neutrophils

AD Reuven, BW Mwaura, JB Bliska - bioRxiv, 2024 - ncbi.nlm.nih.gov
Pseudomonas aeruginosa is an opportunistic bacterial pathogen responsible for a large
percentage of airway infections that cause morbidity and mortality in immunocompromised …

Role of Pseudomonas aeruginosa type III effectors in disease

J Engel, P Balachandran - Current opinion in microbiology, 2009 - Elsevier
Pseudomonas aeruginosa uses a type III secretion system (T3SS) to directly inject four
known effectors into host cells. ExoU is a potent cytotoxin with phospholipase A2 activity that …

Intracellular replication of Pseudomonas aeruginosa in epithelial cells requires suppression of the caspase-4 inflammasome

AR Kroken, KA Klein, PS Mitchell, V Nieto, EJ Jedel… - Msphere, 2023 - Am Soc Microbiol
Pathogenesis of Pseudomonas aeruginosa infections can include bacterial survival inside
epithelial cells. Previously, we showed that this involves multiple roles played by the type …

Pseudomonas aeruginosa ExoS Induces Intrinsic Apoptosis in Target Host Cells in a Manner That is Dependent on its GAP Domain Activity

A Kaminski, KH Gupta, JW Goldufsky, HW Lee… - Scientific reports, 2018 - nature.com
Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that causes serious
infections in immunocompromised individuals and cystic fibrosis patients. ExoS and ExoT …

The Pseudomonas aeruginosa Type III secretion system plays a dual role in the regulation of caspase‐1 mediated IL‐1β maturation

M Galle, P Schotte, M Haegman… - Journal of cellular …, 2008 - Wiley Online Library
Pseudomonas aeruginosa is an opportunistic bacterial pathogen that forms a serious
problem for immunocompromised patients and also the leading cause of mortality in cystic …