Insulin and growth hormone balance: implications for obesity
Disruption of endocrine hormonal balance (ie, increased levels of insulin, and reduced
levels of growth hormone, GH) often occurs in pre‐obesity and obesity. Using distinct …
levels of growth hormone, GH) often occurs in pre‐obesity and obesity. Using distinct …
Elevated GH/IGF-I, due to somatotrope-specific loss of both IGF-I and insulin receptors, alters glucose homeostasis and insulin sensitivity in a diet-dependent manner
MD Gahete, J Cordoba-Chacon, CV Anadumaka… - …, 2011 - academic.oup.com
A unique mouse model was developed with elevated endogenous GH (2-to 3-fold) and IGF-I
(1.2-to 1.4-fold), due to somatotrope-specific Cre-mediated inactivation of IGF-I receptor …
(1.2-to 1.4-fold), due to somatotrope-specific Cre-mediated inactivation of IGF-I receptor …
The GH/IGF-1 axis in obesity: pathophysiology and therapeutic considerations
DE Berryman, CAM Glad, EO List… - Nature Reviews …, 2013 - nature.com
Obesity has become one of the most common medical problems in developed countries,
and this disorder is associated with high incidences of hypertension, dyslipidaemia …
and this disorder is associated with high incidences of hypertension, dyslipidaemia …
The intricate role of growth hormone in metabolism
A Vijayakumar, S Yakar, D LeRoith - Frontiers in endocrinology, 2011 - frontiersin.org
Growth hormone (GH), a master regulator of somatic growth, also regulates carbohydrate
and lipid metabolism via complex interactions with insulin and insulin-like growth factor-1 …
and lipid metabolism via complex interactions with insulin and insulin-like growth factor-1 …
[PDF][PDF] Increased adiposity and insulin correlates with the progressive suppression of pulsatile GH secretion during weight gain
Pathological changes associated with obesity are thought to contribute to GH deficiency.
However, recent observations suggest that impaired GH secretion relative to excess calorie …
However, recent observations suggest that impaired GH secretion relative to excess calorie …
Growth hormone and adipose tissue: beyond the adipocyte
DE Berryman, EO List, L Sackmann-Sala… - Growth Hormone & IGF …, 2011 - Elsevier
The last two decades have seen resurgence in research focused on adipose tissue. In part,
the enhanced interest stems from an alarming increase in obesity rates worldwide. However …
the enhanced interest stems from an alarming increase in obesity rates worldwide. However …
Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function
RM Luque, RD Kineman - Endocrinology, 2006 - academic.oup.com
There is a negative relationship between obesity and GH. However, it is not known how
metabolic changes, associated with obesity, lead to a reduction in GH output. This study …
metabolic changes, associated with obesity, lead to a reduction in GH output. This study …
The role of the growth hormone/insulin-like growth factor system in visceral adiposity
MS Lewitt - Biochemistry insights, 2017 - journals.sagepub.com
There is substantial evidence that the growth hormone (GH)/insulin-like growth factor (IGF)
system is involved in the pathophysiology of obesity. Both GH and IGF-I have direct effects …
system is involved in the pathophysiology of obesity. Both GH and IGF-I have direct effects …
Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms
MD Gahete, J Córdoba-Chacón, Q Lin… - …, 2013 - academic.oup.com
IGF-I is considered a primary inhibitor of GH secretion. Insulin may also play an important
role in regulating GH levels because insulin, like IGF-I, can suppress GH synthesis and …
role in regulating GH levels because insulin, like IGF-I, can suppress GH synthesis and …
Exploring the therapeutic potential of targeting GH and IGF-1 in the management of obesity: Insights from the interplay between these hormones and metabolism
S Al-Samerria, S Radovick - International journal of molecular sciences, 2023 - mdpi.com
Obesity is a growing public health problem worldwide, and GH and IGF-1 have been studied
as potential therapeutic targets for managing this condition. This review article aims to …
as potential therapeutic targets for managing this condition. This review article aims to …