Obesity is associated with an increased risk for the development of type 2 diabetes and
vascular complications. Advanced glycation end products are increased in adipose tissue …

Adipocyte and β-cell dysfunction and macrophage-related chronic inflammation are critical
for the development of obesity-related insulin resistance and type 2 diabetes mellitus …

Background Metabolic inflammation is an essential event in obesity-induced diabetes and
insulin resistance. In obesity, an increasing number of macrophages recruited into visceral …

Metformin (MET) has been demonstrated to have favorable impact on nonalcoholic fatty liver
disease (NAFLD); however, the combined effect of this drug with p-coumaric acid (PCA) on …

Insulin resistance and a progressive decline in functional β‐cell mass are hallmarks of
developing type 2 diabetes (T2D). Thus, searching for natural, low‐cost compounds to target …

Obesity, along with its related complications, is a serious health problem worldwide. Many
studies reported the anti-diabetic effect of phlorizin, while little is known about its anti-obesity …

Obesity and its associated metabolic disorders are related to the onset of fatty liver and the
balance of white adipose tissue (WAT) and brown adipose tissue (BAT). We hypothesized …

Background To date, there is only scare evidence characterizing the temporal features and
progression of metabolic dysfunction in high-fat diet (HFD)-fed obese mice. Hence, its …

Adipose tissue (AT) has a modulating role in obesity-induced metabolic complications like
type 2 diabetes mellitus (T2DM) via the production of so-called adipokines such as leptin …

Aims The therapeutic effects of spermidine on preexisting obese mice have been not fully
elucidated. In this study, we assessed the anti-obesity impact of spermidine on high-fat diet …