Background Mechanisms underlying the attenuation of body weight gain and insulin
resistance in response to high fat diet (HFD) by the curry compound curcumin need to be …

Environmental endocrine disruptors (EDCs), including bisphenol-A (BPA), have been
recently involved in obesity and diabetes by dysregulating adipose tissue function. Our aim …

Objective Dietary methionine restriction (MR) reduces adiposity and hepatic lipids and
increases overall insulin sensitivity in part by reducing lipogenic gene expression in liver …

Abstract Gallic acid [3, 4, 5-trihydroxybenzoic acid (GA)], a natural phytochemical, is known
to have a variety of cellular functions including beneficial effects on metabolic syndromes …

High activation of the angiotensin-converting enzyme (ACE)/(angiotensin-II type 1 receptor)
AT1r axis is closely linked to pro-inflammatory effects and liver damage. The aim of this …

Insulin resistance impairs postprandial glucose uptake through glucose transporter type 4
(GLUT4) and is the primary defect preceding type 2 diabetes. We previously generated an …

Background White adipose tissue (WAT) is important for the maintenance of metabolic
homeostasis, and metabolic syndrome is sometimes associated with WAT dysfunction in …

Adipose tissue is a critical mediator in obesity-induced insulin resistance. Previously we
have demonstrated that pharmacological lowering of glycosphingolipids and subsequently …

Glycolipid metabolism disorder is one of the causes of type 2 diabetes (T2D). Alternate-day
fasting (ADF) is an effective dietary intervention to counteract T2D. The present study is …

Skeletal muscle and adipose tissues are known to be two important insulin target sites.
Therefore, lipid induced insulin resistance in these tissues greatly contributes in the …