Cellular gene modulation of HIV-infected CD4 T cells in response to serial treatment with the histone deacetylase inhibitor vorinostat
JW Maxwell, SD Falcinelli, A Nefedov… - Journal of …, 2020 - Am Soc Microbiol
Histone deacetylase inhibitors (HDACi) are the most widely studied HIV latency-reversing
agents (LRAs). The HDACi suberoylanilide hydroxamic acid (vorinostat [VOR]) has been …
agents (LRAs). The HDACi suberoylanilide hydroxamic acid (vorinostat [VOR]) has been …
The Histone Deacetylase Inhibitor Vorinostat (SAHA) Increases the Susceptibility of Uninfected CD4+ T Cells to HIV by Increasing the Kinetics and Efficiency of …
MB Lucera, CA Tilton, H Mao, C Dobrowolski… - Journal of …, 2014 - Am Soc Microbiol
Latently infected cells remain a primary barrier to eradication of HIV-1. Over the past decade,
a better understanding of the molecular mechanisms by which latency is established and …
a better understanding of the molecular mechanisms by which latency is established and …
[HTML][HTML] Interval dosing with the HDAC inhibitor vorinostat effectively reverses HIV latency
NM Archin, JL Kirchherr, JAM Sung… - The Journal of …, 2017 - Am Soc Clin Investig
BACKGROUND. The histone deacetylase (HDAC) inhibitor vorinostat (VOR) can increase
HIV RNA expression in vivo within resting CD4+ T cells of aviremic HIV+ individuals …
HIV RNA expression in vivo within resting CD4+ T cells of aviremic HIV+ individuals …
HIV-1 Expression Within Resting CD4+ T Cells After Multiple Doses of Vorinostat
NM Archin, R Bateson, MK Tripathy… - The Journal of …, 2014 - academic.oup.com
Background. A single dose of the histone deacetylase inhibitor vorinostat (VOR) up-
regulates HIV RNA expression within resting CD4+ T cells of treated, aviremic human …
regulates HIV RNA expression within resting CD4+ T cells of treated, aviremic human …
[HTML][HTML] Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy
JH Elliott, F Wightman, A Solomon, K Ghneim… - PLoS …, 2014 - journals.plos.org
Human immunodeficiency virus (HIV) persistence in latently infected resting memory CD4+
T-cells is the major barrier to HIV cure. Cellular histone deacetylases (HDACs) are important …
T-cells is the major barrier to HIV cure. Cellular histone deacetylases (HDACs) are important …
[HTML][HTML] Modeling the Effects of Vorinostat In Vivo Reveals both Transient and Delayed HIV Transcriptional Activation and Minimal Killing of Latently Infected Cells
Recent efforts to cure human immunodeficiency virus type-1 (HIV-1) infection have focused
on developing latency reversing agents as a first step to eradicate the latent reservoir. The …
on developing latency reversing agents as a first step to eradicate the latent reservoir. The …
[PDF][PDF] Modeling the Effects of Vorinostat
Recent efforts to cure human immunodeficiency virus type-1 (HIV-1) infection have focused
on developing latency reversing agents as a first step to eradicate the latent reservoir. The …
on developing latency reversing agents as a first step to eradicate the latent reservoir. The …
In Vitro Reactivation of Replication-Competent and Infectious HIV-1 by Histone Deacetylase Inhibitors
R Banga, FA Procopio, M Cavassini… - Journal of virology, 2016 - Am Soc Microbiol
The existence of long-lived HIV-1-infected resting memory CD4 T cells is thought to be the
primary obstacle to HIV-1 eradication. In the search for novel therapeutic approaches that …
primary obstacle to HIV-1 eradication. In the search for novel therapeutic approaches that …
[HTML][HTML] Transcriptional modulation of human endogenous retroviruses in primary CD4+ T cells following vorinostat treatment
CH White, N Beliakova-Bethell, SM Lada… - Frontiers in …, 2018 - frontiersin.org
The greatest obstacle to a cure for HIV is the provirus that integrates into the genome of the
infected cell and persists despite antiretroviral therapy. A “shock and kill” approach has been …
infected cell and persists despite antiretroviral therapy. A “shock and kill” approach has been …
Integrated Assessment of Viral Transcription, Antigen Presentation, and CD8+ T Cell Function Reveals Multiple Limitations of Class I-Selective Histone Deacetylase …
Clinical trials investigating histone deacetylase inhibitors (HDACi) to reverse HIV-1 latency
aim to expose reservoirs in antiretroviral (ARV)-treated individuals to clearance by immune …
aim to expose reservoirs in antiretroviral (ARV)-treated individuals to clearance by immune …