Dose-responsive gene expression in suberoylanilide hydroxamic acid-treated resting CD4+ T cells
B Reardon, N Beliakova-Bethell, CA Spina… - AIDS, 2015 - journals.lww.com
Design: Persistent latently infected CD4+ T cells represent a major obstacle to HIV
eradication. Histone deacetylase inhibitors (HDACis) are a proposed activation therapy …
eradication. Histone deacetylase inhibitors (HDACis) are a proposed activation therapy …
Polyamides reveal a role for repression in latency within resting T cells of HIV-infected donors
L Ylisastigui, JJ Coull, VC Rucker… - The Journal of …, 2004 - academic.oup.com
Background. The persistence of human immunodeficiency virus (HIV) type 1 within resting
CD4+ T cells poses a daunting therapeutic challenge. Histone deacetylase (HDAC)-1, a …
CD4+ T cells poses a daunting therapeutic challenge. Histone deacetylase (HDAC)-1, a …
Harmine enhances the activity of the HIV-1 latency-reversing agents ingenol A and SAHA
JP Taylor, LH Armitage, DL Aldridge, MN Cash… - Biology …, 2020 - journals.biologists.com
Infection with human immunodeficiency virus 1 (HIV-1) remains incurable because long-
lived, latently-infected cells persist during prolonged antiretroviral therapy. Attempts to …
lived, latently-infected cells persist during prolonged antiretroviral therapy. Attempts to …
Temporal transcriptional response to latency reversing agents identifies specific factors regulating HIV-1 viral transcriptional switch
NJ Venkatachari, JM Zerbato, S Jain, AE Mancini… - Retrovirology, 2015 - Springer
Background Latent HIV-1 reservoirs are identified as one of the major challenges to achieve
HIV-1 cure. Currently available strategies are associated with wide variability in outcomes …
HIV-1 cure. Currently available strategies are associated with wide variability in outcomes …
Human endogenous retrovirus (HERV) expression is not induced by treatment with the histone deacetylase (HDAC) inhibitors in cellular models of HIV-1 latency
T Hurst, M Pace, A Katzourakis, R Phillips… - Retrovirology, 2016 - Springer
Background While antiretroviral therapies have improved life expectancy and reduced viral
loads in HIV-1-positive individuals, the cessation of treatment results in a rebound of viral …
loads in HIV-1-positive individuals, the cessation of treatment results in a rebound of viral …
Search for small molecule activators of latent HIV
R Geleziunas, G Stepan, G Wei, H Yu, M Graupe… - Retrovirology, 2012 - Springer
Reservoirs of HIV that persist during ART represent barriers to eradication of this virus. One
well documented reservoir of latent HIV is found in memory CD4+ T-cells. Identifying means …
well documented reservoir of latent HIV is found in memory CD4+ T-cells. Identifying means …
Histone deacetylase inhibitors and HIV latency
DM Margolis - Current Opinion in HIV and AIDS, 2011 - journals.lww.com
Histone deacetylase inhibitors and HIV latency : Current Opinion in HIV and AIDS Histone
deacetylase inhibitors and HIV latency : Current Opinion in HIV and AIDS Log in or Register …
deacetylase inhibitors and HIV latency : Current Opinion in HIV and AIDS Log in or Register …
Mixed effects of suberoylanilide hydroxamic acid (SAHA) on the host transcriptome and proteome and their implications for HIV reactivation from latency
CH White, HE Johnston, B Moesker, A Manousopoulou… - Antiviral research, 2015 - Elsevier
Suberoylanilide hydroxamic acid (SAHA) has been assessed in clinical trials as part of a
“shock and kill” strategy to cure HIV-infected patients. While it was effective at inducing …
“shock and kill” strategy to cure HIV-infected patients. While it was effective at inducing …
[HTML][HTML] The Suv39H1 methyltransferase inhibitor chaetocin causes induction of integrated HIV-1 without producing a T cell response
W Bernhard, K Barreto, A Saunders, MS Dahabieh… - FEBS letters, 2011 - Elsevier
Latent HIV-1 (human immunodeficiency virus-1) provirus is unaffected by current AIDS
(acquired immunodeficiency syndrome) therapies. We show here that chaetocin, an …
(acquired immunodeficiency syndrome) therapies. We show here that chaetocin, an …
Histone deacetylase inhibitor Scriptaid reactivates latent HIV-1 promoter by inducing histone modification in in vitro latency cell lines
H Ying, Y Zhang, S Lin, Y Han… - … journal of molecular …, 2010 - spandidos-publications.com
Human immunodeficiency virus type 1 (HIV-1) latency remains a major problem for the
eradication of viruses in infected individuals undergoing highly active anti-retroviral therapy …
eradication of viruses in infected individuals undergoing highly active anti-retroviral therapy …