[HTML][HTML] Identification of isoform-selective hydroxamic acid derivatives that potently reactivate HIV from latency
Objectives Current antiretroviral therapy can suppress HIV replication, increase CD4 count
and result in increased lifespan. However, it cannot eradicate the virus due to the presence …
and result in increased lifespan. However, it cannot eradicate the virus due to the presence …
[HTML][HTML] Latency reversal agents affect differently the latent reservoir present in distinct CD4+ T subpopulations
J Grau-Expósito, L Luque-Ballesteros, J Navarro… - PLoS …, 2019 - journals.plos.org
Latency reversal agents (LRAs) have proven to induce HIV-1 transcription in vivo but are
ineffective at decreasing the size of the latent reservoir in antiretroviral treated patients. The …
ineffective at decreasing the size of the latent reservoir in antiretroviral treated patients. The …
Latency reversal and viral clearance to cure HIV-1
DM Margolis, JV Garcia, DJ Hazuda, BF Haynes - Science, 2016 - science.org
BACKGROUND A central challenge to emerging efforts to cure HIV infection is the
persistence of quiescent but replication-competent proviral genomes in resting CD4+ T …
persistence of quiescent but replication-competent proviral genomes in resting CD4+ T …
Flavonoid-based inhibition of cyclin-dependent kinase 9 without concomitant inhibition of histone deacetylases durably reinforces HIV latency
C Schonhofer, J Yi, A Sciorillo… - Biochemical …, 2021 - Elsevier
While combination antiretroviral therapy (cART) durably suppresses HIV replication, virus
persists in CD4+ T-cells that harbor latent but spontaneously inducible and replication …
persists in CD4+ T-cells that harbor latent but spontaneously inducible and replication …
[HTML][HTML] HDAC inhibition induces HIV-1 protein and enables immune-based clearance following latency reversal
G Wu, M Swanson, A Talla, D Graham, J Strizki… - JCI insight, 2017 - ncbi.nlm.nih.gov
Promising therapeutic approaches for eradicating HIV include transcriptional activation of
provirus from latently infected cells using latency-reversing agents (LRAs) and immune …
provirus from latently infected cells using latency-reversing agents (LRAs) and immune …
[HTML][HTML] Broad activation of latent HIV-1 in vivo
K Barton, B Hiener, A Winckelmann… - Nature …, 2016 - nature.com
The 'shock and kill'approach to cure human immunodeficiency virus (HIV) includes
transcriptional induction of latent HIV-1 proviruses using latency-reversing agents (LRAs) …
transcriptional induction of latent HIV-1 proviruses using latency-reversing agents (LRAs) …
c-Myc and Sp1 contribute to proviral latency by recruiting histone deacetylase 1 to the human immunodeficiency virus type 1 promoter
G Jiang, A Espeseth, DJ Hazuda… - Journal of virology, 2007 - Am Soc Microbiol
Histone deacetylase (HDAC) inhibitors such as valproic acid (VPA) induce the expression of
quiescent proviral human immunodeficiency virus type 1 (HIV-1) and may deplete proviral …
quiescent proviral human immunodeficiency virus type 1 (HIV-1) and may deplete proviral …
[HTML][HTML] Chidamide, a histone deacetylase inhibitor-based anticancer drug, effectively reactivates latent HIV-1 provirus
W Yang, Z Sun, C Hua, Q Wang, W Xu, Q Deng… - Microbes and …, 2018 - Elsevier
Although combination antiretroviral therapy (cART) is highly effective in suppressing human
immunodeficiency virus type 1 (HIV-1) replication, it fails to eradicate the virus from HIV-1 …
immunodeficiency virus type 1 (HIV-1) replication, it fails to eradicate the virus from HIV-1 …
The molecular biology of HIV latency
HIV remains incurable due to the existence of a reservoir of cells that harbor intact integrated
genomes of the virus in the absence of viral replication. This population of infected cells …
genomes of the virus in the absence of viral replication. This population of infected cells …
Neurotoxicity with high-dose disulfiram and vorinostat used for HIV latency reversal
Objective: The aim of this study was to examine whether administering both vorinostat and
disulfiram to people with HIV (PWH) on antiretroviral therapy (ART) is well tolerated and can …
disulfiram to people with HIV (PWH) on antiretroviral therapy (ART) is well tolerated and can …