Wnt signaling regulates the proliferation potential and lineage commitment of human umbilical cord derived mesenchymal stem cells

G Jothimani, R Di Liddo, S Pathak, M Piccione… - Molecular biology …, 2020 - Springer
Relatively less is known about the interactions that tightly regulate the mesenchymal stem
cells (MSCs) to maintain their pluripotency. Recent studies reports that Wnt proteins might …

Involvement of WNT signaling in the regulation of gestational age‐dependent umbilical cord‐derived mesenchymal stem cell proliferation

S Iwatani, A Shono, M Yoshida, K Yamana… - Stem cells …, 2017 - Wiley Online Library
Mesenchymal stem cells (MSCs) are a heterogeneous cell population that is isolated initially
from the bone marrow (BM) and subsequently almost all tissues including umbilical cord …

Stemness gene expression profile analysis in human umbilical cord mesenchymal stem cells

MY Meng, W Pang, LH Jiang, YH Liu… - Experimental …, 2012 - journals.sagepub.com
Umbilical cord mesenchymal stem cells (UC-MSCs) have several advantages for clinical
therapy: the material is easily obtainable, the donation procedure is painless and there is …

Multi-lineage differentiation of mesenchymal stem cells–To Wnt, or not Wnt

M Visweswaran, S Pohl, F Arfuso, P Newsholme… - The international journal …, 2015 - Elsevier
Mesenchymal stem cells (MSCs) are multipotent precursor cells originating from several
adult connective tissues. MSCs possess the ability to self-renew and differentiate into …

Different balance of Wnt signaling in adult and fetal bone marrow-derived mesenchymal stromal cells

MM Paciejewska, MW Maijenburg… - Stem cells and …, 2016 - liebertpub.com
Mesenchymal stromal cells (MSCs) are applied as novel therapeutics for their regenerative
and immune-suppressive capacities. Clinical applications, however, require extensive …

Molecular mechanism underlying the difference in proliferation between placenta‐derived and umbilical cord‐derived mesenchymal stem cells

X Feng, J Liu, Y Xu, J Zhu, W Chen… - Journal of cellular …, 2020 - Wiley Online Library
The placenta and umbilical cord are pre‐eminent candidate sources of mesenchymal stem
cells (MSCs). However, placenta‐derived MSCs (P‐MSCs) showed greater proliferation …

Canonical and non‐canonical Wnts differentially affect the development potential of primary isolate of human bone marrow mesenchymal stem cells

D Baksh, RS Tuan - Journal of cellular physiology, 2007 - Wiley Online Library
This study examines the role of Wnt signaling events in regulating the differential potential of
mesenchymal stem cells (MSCs) from adult bone marrow (BM). Immunohistochemical …

Effects of Wnt signaling on proliferation and differentiation of human mesenchymal stem cells

J De Boer, HJ Wang, C Van Blitterswijk - Tissue engineering, 2004 - liebertpub.com
Mesenchymal stem cells are pluripotent cells from bone marrow, which can be differentiated
into the osteogenic, chondrogenic, and adipogenic lineages in vitro and are a source of cells …

Activation of non-canonical Wnt/JNK pathway by Wnt3a is associated with differentiation fate determination of human bone marrow stromal (mesenchymal) stem cells

W Qiu, L Chen, M Kassem - Biochemical and biophysical research …, 2011 - Elsevier
The canonical Wnt signaling pathway can determine human bone marrow stromal
(mesenchymal) stem cell (hMSC) differentiation fate into osteoblast or adipocyte lineages …

[HTML][HTML] Single-cell transcriptome analysis of uncultured human umbilical cord mesenchymal stem cells

S Zhang, JY Wang, B Li, F Yin, H Liu - Stem Cell Research & Therapy, 2021 - Springer
Umbilical cord mesenchymal stem cells (UC-MSCs) have certain advantages over other
MSCs and about 300 clinical trials have been registered using UC-MSCs to treat diseases …