Amyotrophic lateral sclerosis (ALS) is a motor neuron disease characterized by progressive
loss of upper and lower motor neurons. Despite significant scientific efforts in the last …

Objective To explore whether the repeat lengths of the chromosome 9 open reading frame
72 (C9orf72) gene and the ataxin-2 (ATXN2) gene in amyotrophic lateral sclerosis (ALS) …

Amyotrophic lateral sclerosis (ALS) is a progressively fatal neuromuscular disorder
classically characterized by loss of upper and lower motor neurons from the cortex to the …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease
characterized by selective death of upper motor neurons (UMNs) and lower motor neurons …

We investigated whether the C9orf72 repeat expansion is associated with specific clinical
features, comorbidities, and prognosis in patients with amyotrophic lateral sclerosis (ALS). A …

A hexanucleotide repeat expansion (HRE) in the C9orf72 gene has been identified as the
most common mutation in amyotrophic lateral sclerosis (ALS) among Caucasian …

Amyotrophic lateral sclerosis (ALS) remains among the most intriguing of the degenerative
disorders. Despite is known existence for 150 years, we do not yet understand its …

The C9orf72 hexanucleotide repeat (HR) expansion is the main genetic cause of
amyotrophic lateral sclerosis (ALS), with expansion size from 30 to> 4000 units. Normal …

Amyotrophic lateral sclerosis (ALS) is a late-onset fatal neurodegenerative disease affecting
motor neurons with an incidence of about 1/100,000. Most ALS cases are sporadic, but 5 …

Background Hexanucleotide repeat expansion in C9orf72 is defined as major causative
factor for familial Amyotrophic Lateral Sclerosis (ALS). Yet, the mutation frequency varies …