Aging is associated with an increased risk of cancer, possibly in part because of an age-
related increase in mutations in normal tissues. Due to their extremely low abundance …

Cancer is a disease of aging fueled by the accumulation of somatic mutations. While
mutations in tumors are well characterized, little is known about the early mutational …

Background To shed light on the earliest events in oncogenesis, there is growing interest in
understanding the mutational landscapes of normal tissues across ages. In the last decade …

Spontaneously occurring mutations accumulate in somatic cells throughout a person's
lifetime. The majority of these mutations do not have a noticeable effect, but some can alter …

Somatic mutations have long been implicated in aging and disease, but their impact on
fitness and function is difficult to assess. Here by analysing human cancer genomes we …

The genome of multicellular organisms carries the hereditary information necessary for the
development of all organs and tissues and to maintain function in adulthood. To ensure the …

A widely accepted paradigm in cancer research holds that the development of cancers is
rate limited by the occurrence of oncogenic mutations. In particular, the exponential rise in …

Background The lifelong accumulation of somatic mutations underlies age-related
phenotypes and cancer. Mutagenic forces are thought to shape the genome of aging cells in …

From conception to death, human cells accumulate somatic mutations in their genomes.
These mutations can contribute to the development of cancer and non-malignant diseases …

Editorial summary Recent sequencing studies on healthy skin and esophagus have found
that, as we age, these tissues become colonized by mutant clones of cells carrying driver …