Background: Airway obstruction in asthma is driven by airway smooth muscle (ASM)
contraction. Airway obstruction can be induced extrinsically by direct stimulation of ASM with …

Background Airway obstruction (AO) in asthma is driven by airway smooth muscle (ASM)
contraction. AO can be induced extrinsically by direct stimulation of ASM with contractile …

Airway obstruction (AO) in asthma is driven by airway smooth muscle (ASM) contraction.
Direct stimulation of ASM with contractile agonists, or indirect with antigens are related to …

Excessive airway obstruction is the cause of symptoms and abnormal lung function in
asthma. As airway smooth muscle (ASM) is the effecter controlling airway calibre, it is …

It has long been known that airway smooth muscle (ASM) contraction contributes
significantly to the reversible airflow obstruction that defines asthma. It has also been …

Airway hyperresponsiveness and obstruction are cardinal features of asthma. Compelling
evidence now suggests that the key features of asthma in part are due to intrinsic differences …

The cause-and-effect relationship between airway smooth muscle (ASM) remodeling and
airway hyperresponsiveness (AHR) following allergen challenge is not well established …

RATIONALE: Excessive bronchoconstriction plays a central role in airway
hyperresponsiveness in asthma, but it is unclear whether the airway smooth muscle (ASM) …

It remains unclear whether airway smooth muscle (ASM) mechanics is altered in asthma.
While efforts have originally focussed on contractile force, some evidence points to an …

Respiratory symptoms are largely caused by obstruction of the airways. In asthma, airway
narrowing mediated by airway smooth muscle (ASM) contraction contributes significantly to …