Background Sex is an important covariate of epigenome-wide association studies due to its
strong influence on DNA methylation patterns across numerous genomic positions …

DNA methylation influences predisposition, development and prognosis for many diseases,
including cancer. However, it is not uncommon to encounter samples with incorrect sex …

Background Sex differences are known to play a role in disease aetiology, progression and
outcome. Previous studies have revealed autosomal epigenetic differences between males …

Sex is a modulator of health that has been historically overlooked in biomedical research.
Recognizing this knowledge gap, funding agencies now mandate the inclusion of sex as a …

Sex differences in methylation status have been observed in specific gene-disease studies
and healthy methylation variation studies, but little work has been done to study the impact …

Epigenetic sex differences and their resulting implications for human health have been
studied for about a decade. The objective of this paper is to use permutation-based …

Abstract Epigenome-Wide Association Study (EWAS) has become an effective strategy to
explore epigenetic basis of complex traits. Over the past decade, a large amount of …

Background Genetic data are known to harbor information about human demographics, and
genotyping data are commonly used for capturing ancestry information by leveraging …

Background DNA methylation, an important epigenetic mark, is well known for its regulatory
role in gene expression, especially the negative correlation in the promoter region …

Background Modification of DNA by methylation of cytosines at CpG dinucleotides is a
widespread phenomenon that leads to changes in gene expression, thereby influencing and …