Profound and debilitating fatigue is the most common complaint reported among individuals
with autoimmune disease, such as systemic lupus erythematosus, multiple sclerosis, type 1 …

Chronic fatigue is a common, poorly understood and disabling phenomenon in many
diseases. We aim to provide an overview of fatigue in chronic autoimmune and inflammatory …

Many patients with systemic immune-inflammatory and neuro-inflammatory disorders,
including depression, rheumatoid arthritis, systemic lupus erythematosus, Sjögren's disease …

Background The genesis of severe fatigue and disability in people following acute pathogen
invasion involves the activation of Toll-like receptors followed by the upregulation of …

Fatigue is a complex phenomenon and an important health concern for many people with
chronic inflammatory rheumatic diseases, such as rheumatoid arthritis, psoriatic arthritis …

Multiple sclerosis (MS) is an immune mediated disease of the central nervous system (CNS)
and the leading cause of non-traumatic disability among young and middle-aged adults in …

Fatigue is a highly disabling symptom in various medical conditions. While inflammation has
been suggested as a potential contributor to the development of fatigue, underlying …

The exact nature and pathophysiology of fatigue remain largely elusive despite its high
prevalence in physically ill patients. Studies on the relationship between the immune system …

Depression and fatigue are conditions responsible for heavy global societal burden,
especially in patients already suffering from chronic diseases. These symptoms have been …

Systemic lupus erythematosus is a chronic inflammatory autoimmune disease often
characterized by fatigue, with significant effects on physical functioning and wellbeing. The …