[HTML][HTML] A Broad Spectrum Antiparasitic Activity of Organotin (IV) Derivatives and Its Untargeted Proteomic Profiling Using Leishmania donovani

O Hayat, N Ullah, M Sirajuddin, MA Giardini… - Pathogens, 2022 - mdpi.com
Metals have been used in medicine since ancient times for the treatment of different ailments
with various elements such as iron, gold and arsenic. Metal complexes have also been …

Potentially bioactive organotin (IV) compounds: synthesis, characterization, in vitro bioactivities and interaction with SS-DNA

M Sirajuddin, S Ali, V McKee, M Sohail… - European journal of …, 2014 - Elsevier
Fourteen new organotin (IV) complexes with general formula R 2 SnL 2 or R 3 SnL where
R= CH 3, C 2 H 5, C 4 H 9, C 6 H 5, C 6 H 11, CH 2–C 6 H 5, C (CH 3) 3, C 8 H 17 and L= N …

Organotin (IV) complexes of carboxylate derivative as potential chemotherapeutic agents against Leishmania

HQ Qurrat-ul-Ain, A Nadhman, M Sirajuddin… - Inorganica Chimica …, 2014 - Elsevier
The aim of the present research is to search for new antileishmanial drugs as potential
chemotherapeutic agents. We have some newly synthesized organotin (IV) based peptide …

Organogold (III)-dithiocarbamate compounds and their coordination analogues as anti-tumor and anti-leishmanial metallodrugs

AL de Andrade Querino, AM de Sousa… - Journal of Inorganic …, 2023 - Elsevier
The limited chemical stability of gold (III)-based compounds in physiological environment
has been a challenge in drug discovery, and organometallic chemistry might provide the …

[HTML][HTML] Synthesis, spectroscopic characterization, antileishmanial, DNA binding, antioxidant, cytotoxicity, antifungal and antibacterial studies of organotin (IV) …

S Hussain, S Shujah, A Rehman, ST Hussain… - Arabian Journal of …, 2023 - Elsevier
Six new organotin (IV) complexes,[Bu 2 SnL](1),[Me 2 SnL](2),[Me 3 SnL](3),[Bu 3
SnL](4),[Ph 3 SnL](5) and [(n-Oct 2 SnL](6) have been synthesized from the reaction of 4-((5 …

Investigation of the antileishmanial activity and mechanisms of action of acetyl-thiohydantoins

BT da Silva Bortoleti, MD Gonçalves… - Chemico-Biological …, 2022 - Elsevier
The currently available treatment options for leishmaniasis are associated with high costs,
severe side effects, and high toxicity. In previous studies, thiohydantoins demonstrated some …

From synthesis to bioactivity: Characterization, crystallography, antimalarial and antimicrobial activities of hydrazone-derived organotin (IV) complexes

A Boora, J Devi, K Lal, T Rom, AK Paul - Inorganica Chimica Acta, 2024 - Elsevier
In the pursuit of therapeutic agents against malarial and microbial infections, a series of
pentacoordinated organotin (IV) complexes [R 2 SnL 1-4] were synthesized through the …

[HTML][HTML] Screening a natural product-based library against kinetoplastid parasites

B Zulfiqar, AJ Jones, ML Sykes, TB Shelper, RA Davis… - Molecules, 2017 - mdpi.com
Kinetoplastid parasites cause vector-borne parasitic diseases including leishmaniasis,
human African trypanosomiasis (HAT) and Chagas disease. These Neglected Tropical …

[HTML][HTML] Development of Thiophene Compounds as Potent Chemotherapies for the Treatment of Cutaneous Leishmaniasis Caused by Leishmania major

F Rodriguez, E Iniguez, G Pena Contreras, H Ahmed… - Molecules, 2018 - mdpi.com
Leishmania major (L. major) is a protozoan parasite that causes cutaneous leishmaniasis.
About 12 million people are currently infected with an annual incidence of 1.3 million cases …

[HTML][HTML] Organotin (IV) esters of 4-maleimido-benzoic acid: synthesis, characterization and in vitro anti-leishmanial effects

MI Khan, MK Baloch, M Ashfaq, S Gul - Journal of the Brazilian …, 2009 - SciELO Brasil
Six new diorganotin (IV) esters with the general composition R2SnL2 (where R: Me (1), Et
(2), Pr (3), Bu (4), Ph (5), Bz (6) and L (7): pN-maleimido-benzoic acid) have been …