In contrast to cats and dogs, here we report that the α2-adrenergic receptor antagonist
yohimbine is emetic and corresponding agonists clonidine and dexmedetomidine behave …

Subtypes (1–4) of the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels
are widely expressed in the central and peripheral nervous systems, as well as the cells of …

Gq and Gβγ protein-dependent phospholipase C (PLC) activation is extensively involved in
G protein-coupled receptor (GPCR)-mediated signaling pathways which are implicated in a …

The anti-emetic mechanism of action of fentanyl to inhibit nicotine (5 mg/kg, sc)-induced
emesis was investigated in Suncus murinus. The anti-emetic action of fentanyl (40 μg/kg, sc) …

The cough and emetic reflexes involve a synchronized firing of motor neurones involved in
respiratory control. Tachykinin NK1 receptor antagonists and 5-HT1A receptor agonists are …

With its five receptor subtypes (D 1–5), dopamine is implicated in a myriad of neurological
illnesses. Dopamine D 2 receptor-based agonist therapy evokes nausea and vomiting. The …

Published studies have shown that the transient receptor potential vanilloid 1 (TRPV1)
receptor agonist, resiniferatoxin (RTX), has pro and antiemetic effects. RTX can suppress …

Research on the mechanisms of emesis has implicated multiple neurotransmitters via both
central (dorsal vagal complex) and peripheral (enteric neurons and enterochromaffin cells) …

This study introduces Cryptotis parva (the least shrew) as a new dopaminergic animal model
of emesis. The potential emetogenic effects of a nonselective dopamine agonist …

The dihydropyridine l-type calcium (Ca 2+) channel blockers nifedipine and amlodipine
reduce extracellular Ca 2+ entry into cells. They are widely used for the treatment of …