Mitochondria are well known for their roles as energy and metabolic factory. Mitochondrial
reactive oxygen species (mtROS) refer to superoxide anion radical (• O 2−) and hydrogen …

Mitochondrially generated reactive oxygen species are involved in a myriad of signaling and
damaging pathways in different tissues. In addition, mitochondria are an important target of …

Elevated mitochondrial matrix superoxide and/or hydrogen peroxide concentrations drive a
wide range of physiological responses and pathologies. Concentrations of superoxide and …

For over 40 years, mitochondrial reactive oxygen species (ROS) production and balance
has been studied in the context of oxidative distress and tissue damage. However, research …

Reactive oxygen species (ROS) play an important role in physiological and pathological
processes. In recent years, a feed-forward regulation of the ROS sources has been reported …

Mitochondria are the major energy producers within a cell in the form of adenosine
triphosphate by oxidative phosphorylation. Normal mitochondrial metabolism inevitably …

Mitochondria are quantifiably the most important sources of superoxide (O2●−) and
hydrogen peroxide (H2O2) in mammalian cells. The overproduction of these molecules has …

The excessive formation of reactive oxygen species (ROS) and impairment of defensive
antioxidant systems leads to a condition known as oxidative stress. The main source of free …

Mitochondria play an important role in controlling the life and death of a cell. Consequently,
mitochondrial dysfunction leads to a range of human diseases such as ischemia …

Mitochondria in aerobic eukaryotic cells are both the site of energy production and the
formation of harmful species, such as radicals and other reactive oxygen species, known as …