Biofilms: Novel strategies based on antimicrobial peptides

E Galdiero, L Lombardi, A Falanga, G Libralato… - Pharmaceutics, 2019 - mdpi.com
The problem of drug resistance is very worrying and ever increasing. Resistance is due not
only to the reckless use of antibiotics but also to the fact that pathogens are able to adapt to …

Antimicrobial and antibiofilm peptides

A Di Somma, A Moretta, C Canè, A Cirillo, A Duilio - Biomolecules, 2020 - mdpi.com
The increasing onset of multidrug-resistant bacteria has propelled microbiology research
towards antimicrobial peptides as new possible antibiotics from natural sources …

Critical assessment of methods to quantify biofilm growth and evaluate antibiofilm activity of host defence peptides

EF Haney, MJ Trimble, JT Cheng, Q Vallé… - Biomolecules, 2018 - mdpi.com
Biofilms are multicellular communities of bacteria that can adhere to virtually any surface.
Bacterial biofilms are clinically relevant, as they are responsible for up to two-thirds of …

Design and assessment of anti-biofilm peptides: steps toward clinical application

M Dostert, CR Belanger, REW Hancock - Journal of innate immunity, 2019 - karger.com
Highly antibiotic resistant, microbial communities, referred to as biofilms, cause various life-
threatening infections in humans. At least two-thirds of all clinical infections are biofilm …

Combination strategies to enhance the efficacy of antimicrobial peptides against bacterial biofilms

L Grassi, G Maisetta, S Esin, G Batoni - Frontiers in Microbiology, 2017 - frontiersin.org
The great clinical significance of biofilm-associated infections and their inherent
recalcitrance to antibiotic treatment urgently demand the development of novel antibiofilm …

Use of antimicrobial peptides against microbial biofilms: advantages and limits

G Batoni, G Maisetta… - Current medicinal …, 2011 - ingentaconnect.com
The formation of surface-attached cellular agglomerates, the so-called biofilms, contributes
significantly to bacterial resistance to antibiotics and innate host defenses. Bacterial biofilms …

Antibiofilm peptides and peptidomimetics with focus on surface immobilization

A Andrea, N Molchanova, H Jenssen - Biomolecules, 2018 - mdpi.com
Bacterial biofilms pose a major threat to public health, as they are associated with at least
two thirds of all infections. They are highly resilient and render conventional antibiotics …

Antibiofilm peptides: potential as broad-spectrum agents

D Pletzer, REW Hancock - Journal of bacteriology, 2016 - Am Soc Microbiol
The treatment of bacterial diseases is facing twin threats, with increasing bacterial antibiotic
resistance and relatively few novel compounds or strategies under development or entering …

Antibiofilm peptides: overcoming biofilm-related treatment failure

M Dostert, MJ Trimble, REW Hancock - RSC advances, 2021 - pubs.rsc.org
Health leaders and scientists worldwide consider antibiotic resistance among the world's
most dangerous pathogens as one of the biggest threats to global health. Antibiotic …

Antimicrobial peptides as an alternative for the eradication of bacterial biofilms of multi-drug resistant bacteria

JTC Pontes, AB Toledo Borges, CA Roque-Borda… - Pharmaceutics, 2022 - mdpi.com
Bacterial resistance is an emergency public health problem worldwide, compounded by the
ability of bacteria to form biofilms, mainly in seriously ill hospitalized patients. The World …