Migraine afflicts more than 10% of the general population. Although its mechanism is poorly
understood, recent preclinical and clinical evidence has identified calcitonin gene related …

Migraine is a chronic neurological disorder that affects approximately 12% of the population.
The cause of migraine headaches is not yet known, however, when the trigeminal system is …

Ever since their identification, interest in the role of transient receptor potential (TRP)
channels in health and disease has steadily increased. Robust evidence has underlined the …

Migraine is a common and debilitating headache disorder. Although its pathogenesis
remains elusive, abnormal trigeminal and central nervous system activity is likely to play an …

Migraine remains an elusive and poorly understood disease. The uncertainty is reflected by
the currently unsatisfactory acute and prophylactic treatments for this disease. Genetic and …

Migraine is the second-most disabling disease worldwide, and the second most common
neurological disorder. Attacks can last many hours or days, and consist of multiple …

Migraine is among the most prevalent headache disorders and results from dysfunctions
within the trigeminovascular system (TVS). The inflammatory processes that have been …

Migraine is increasingly understood to be a disorder of the brain. In susceptible individuals,
a variety of “triggers” may influence altered central excitability, resulting in the activation and …

The transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily of
channels, is primarily localized to a subpopulation of primary sensory neurons of the …

Background Clinical and experimental studies have pointed to the possible involvement of
the transient receptor potential ankyrin type-1 (TRPA1) channels in migraine pain. In this …