Abstract Endothelin-1 (ET-1) was first characterized as a potent vasoconstrictor and is
overexpressed in the vasculature in different models of hypertension, such as …

Abstract Endothelin-1 (ET-1) is a powerful vasoconstrictor peptide and regulator of blood
flow that plays an important role in blood pressure (BP) elevation in some models of …

Endothelins are powerful vasoconstrictor peptides that also play numerous other functions in
many different organs. Endothelin-1 (ET-1) is the most abundant and important of this family …

Endothelin-1 (ET-1) is overexpressed in the vascular wall in certain models of experimental
hypertension: deoxycorticosterone acetate salt–treated rats, deoxycorticosterone acetate …

Abstract Endothelin-1 (ET-1) is a powerful vasoconstrictor and mitogen that contributes to
blood pressure elevation and related vascular remodeling and target organ damage. ET-1 …

Atherosclerosis is a progressive inflammatory disease of the arterial intima defined by fatty
plaques within the vessel wall. 1 Plaques are characterized by the subendothelial build-up …

Abstract Endothelin-1 (ET-1) exerts a wide range of biologic effects that can influence
systemic blood pressure. Recent studies indicate that increased activity of the ET system in …

The potential role of endothelin-1 (ET-1) in essential hypertension in humans is still subject
to debate. We recently reported strong sodium retention and renal vasoconstriction during …

Endothelin-1 (ET-1) is a vasoconstrictor, proinflammatory and proliferative endothelial cell-
derived peptide that is of significant importance in the regulation of vascular function. It is …

Atherosclerosis, a chronic systemic disease of the vasculature with an inflammatory
component, is the primary cause of cardiovascular morbidity and mortality in industrialized …