The endothelins (ET) are potent 21-amino-acid vasoconstrictor peptides produced in many
different tissues, particularly in the endothelium of blood vessels. ET-1 is the main …

Endothelins are powerful vasoconstrictor peptides that also play numerous other functions in
many different organs. Endothelin-1 (ET-1) is the most abundant and important of this family …

The role of endothelins (ET) in blood pressure elevation remains controversial. Data
supporting involvement of the ET system in different forms of genetic and experimental …

The rapid development of endothelin-receptor antagonists has made the endothelin
pathway a new therapeutic target in the treatment of cardiovascular diseases, only ten years …

Abstract The endothelins, 21-amino-acid peptides produced by the endothelium of blood
vessels and many other tissues such as the kidney, brain, endocrine organs, etc., are potent …

Abstract Endothelin-1 (ET-1) is a powerful vasoconstrictor peptide and regulator of blood
flow that plays an important role in blood pressure (BP) elevation in some models of …

Endothelin-1 is a recently discovered peptide mainly released from endothelial cells.
Hypoxia and ischemia as well as numerous factors such as angiotensin 11, thrombin and …

Endothelin-1 (ET-1) is overexpressed in the vascular wall in certain models of experimental
hypertension: deoxycorticosterone acetate salt–treated rats, deoxycorticosterone acetate …

Endothelin is the most potent mammalian vasoconstrictor yet discovered. Its three isoforms
play leading roles in regulating vascular tone and causing mitogenesis. The isoforms bind to …

Endothelins are potent 21 amino acid vasoconstrictor isopeptides produced in different
vascular tissues, including vascular endothelium. Endothelin-1 is the main endothelin …