Neuropathic pain arises from peripheral nerve injury-induced loss of GABAergic controls in
the spinal cord dorsal horn, resulting in ongoing, often burning pain, and mechanical and …

Neuropathic pain is a chronic debilitating disease characterized by mechanical allodynia
and spontaneous pain. Because symptoms are often unresponsive to conventional methods …

Spinal cord transplants of embryonic cortical GABAergic progenitor cells derived from the
medial ganglionic eminence (MGE) can reverse mechanical hypersensitivity in the mouse …

Among many mechanisms implicated in the development of neuropathic pain after nerve
damage is a profound dysfunction of GABAergic inhibitory controls, manifested by ongoing …

Decreased spinal cord GABAergic inhibition is a major contributor to the persistent
neuropathic pain that can follow peripheral nerve injury. Recently, we reported that restoring …

Neuropathic pain causes severe suffering, and most patients are resistant to current
therapies. A core element of neuropathic pain is the loss of inhibitory tone in the spinal cord …

Injury to the spinal cord or peripheral nerves can lead to the development of allodynia due to
the loss of inhibitory tone involved in spinal sensory function. The potential of intraspinal …

Transplanting embryonic precursors of GABAergic neurons from the medial ganglionic
eminence (MGE) into adult mouse spinal cord ameliorates mechanical and thermal …

The use of cell lines utilized as biologic “minipumps” to provide antinociceptive molecules,
such as GABA, in animal models of pain is a newly developing area in transplantation …

Transplanted precursors halt neuropathic pain | Nature Reviews Neuroscience Skip to main
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