T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological disease that
arises from the oncogenic transformation of developing T cells during T-lymphopoiesis …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic tumor resulting
from the malignant transformation of immature T-cell progenitors. Originally associated with …

T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematopoietic malignancy of
thymocytes affecting preferentially children and adolescents. The disease is heterogeneous …

NOTCH1 plays a central role in T-cell development and, when aberrantly activated, in acute
T-cell lymphoblastic leukemia (T-ALL). As a transmembrane receptor that is ultimately …

T-cell acute lymphoblastic leukemia (T-ALL) is a form of pediatric leukemia that is thought to
be caused by approximately 12 distinct chromosomal translocations that lead to aberrant …

T-cell acute lymphoblastic leukemia (T-ALL) is a highly proliferative hematologic malignancy
that results from the transformation of immature T-cell progenitors. Aberrant cell growth and …

Purpose: NOTCH signaling pathway is essential in T-cell development and NOTCH1
mutations are frequently present in T-cell acute lymphoblastic leukemia (T-ALL). To gain …

NOTCH1 is a prevalent signaling pathway in T cell acute lymphoblastic leukemia (T-ALL),
but crucial NOTCH1 downstream signals and target genes contributing to T-ALL …

T-cell acute lymphoblastic leukemia (T-ALL) is one of the hematological malignancies. With
the applications of chemotherapy regimens and allogeneic hematopoietic stem cell …

T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) is characterized by aberrant
activation of NOTCH1 in over 60% of T-ALL cases. The high prevalence of activating …