Abstract Background The Notch signaling pathway is crucial in T-cell development, Notch 1
mutations are frequently present in T-cell acute lymphoblastic leukemia (T-ALL). To …

Abstract Purpose: Activating Notch-1 mutations are frequent in T-cell acute lymphoblastic
leukemia (T-ALL), occurring in> 50% of patients. In murine models of T-ALL, Notch-1 …

Introduction: Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy.
Although the therapy of ALL has significantly improved, the heterogeneous genetic …

Post-translational modifications of Notch3 and their functional role with respect to Notch3
overexpression in T-cell leukemia are still poorly understood. We identify here a specific …

Genetic studies in T-cell acute lymphoblastic leukemia have uncovered a remarkable
complexity of oncogenic and loss-of-function mutations. Amongst this plethora of genetic …

Activating mutations of NOTCH1 (a well-known oncogene in T-cell acute lymphoblastic
leukemia) are present in∼ 4–13% of chronic lymphocytic leukemia (CLL) cases, where they …

Recent discoveries indicate that gain-of-function mutations in the Notch1 receptor are very
common in human T cell acute lymphoblastic leukemia/lymphoma. This review discusses …

Mutations resulting in overexpression of intracellular Notch1 (ICN1) are frequently observed
in human T cell acute lymphoblastic leukemia (T-ALL). We have determined the …

Activating NOTCH1 mutations are frequent in human T-cell acute lymphoblastic leukemia (T-
ALL) and Notch inhibitors (γ-secretase inhibitors [GSIs]) have produced responses in …

The Notch signaling pathway plays a critical role in maintaining the balance between cell
proliferation, differentiation and apoptosis, and is a highly conserved signaling pathway that …