Deregulated Notch signaling has been extensively linked to T-cell acute lymphoblastic
leukemia (T-ALL). Here, we show a direct relationship between Notch3 receptor and …

Notch signaling controls cell fate decisions of hematopoietic progenitors by inhibiting certain
steps of differentiation and inducing either self-renewal or differentiation toward lymphoid or …

BACKGROUND: This study aimed to determine the prevalence and clinical impact of
neurogenic locus notch homolog protein 1 (NOTCH1) mutations among patients with T cell …

Mammalian Notch homologs were first identified from the involvement of Notch1 in a
recurrent chromosomal translocation in a subset of human T-cell leukemias. The effect of the …

T-cell acute lymphoblastic leukemia (T-ALL) is a hematologic neoplasm characterized by
malignant expansion of immature T cells. Activated NOTCH (NotchIC) and c-MYC …

Recent work with mouse models and human leukemic samples has shown that gain-of-
function mutation (s) in Notch1 is a common genetic event in T-cell acute lymphoblastic …

The Notch pathway is frequently activated in T-cell acute lymphoblastic leukemias (T-ALLs).
Of the Notch receptors, Notch1 is a recurrent target of gain-of-function mutations and Notch3 …

NOTCH1 encodes a transmembrane signaling protein that plays key roles in development
and neoplasia. Its leukemogenic involvement was first revealed by analysis of t (7; 9)(q34; …

The evolutionarily conserved Notch signaling pathway controls diverse events such as cell
fate determination, proliferation, apoptosis, and stem cell maintenance. Dysregulation of this …

The Notch pathway plays a key role in several processes, including stem-cell self-renewal,
proliferation, and cell differentiation. Several studies identified recurrent mutations in …